Mapping Subcortical Brain Alterations in 22q11.2 Deletion Syndrome: Effects of Deletion Size and Convergence With Idiopathic Neuropsychiatric Illness

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Mapping Subcortical Brain Alterations in 22q11.2 Deletion Syndrome - Effects of Deletion Size and Convergence With Idiopathic Neuropsychiatric Illness.pdf(3.51 KB)
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2020
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Abstract
Objective: 22q11.2 deletion syndrome (22q11DS) is among the strongest known genetic risk factors for schizophrenia. Previous studies have reported variable alterations in sub-cortical brain structures in 22q11DS. To better characterize subcortical alterations in 22q11DS, including modulating effects of clinical and genetic heterogeneity, the authors studied a large multicenter neuroimaging cohort from the ENIGMA 22q11.2 Deletion Syndrome Working Group.
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Mouse model, Schizophrenia Spectrum, Volume, Disorders, Children, Morphometry, Behavior, Dosage, Cortex
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https://doi.org/10.1176/appi.ajp.2019.19060583
 https://repositorio.uc.cl/handle/11534/86482
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