GANGLIOSIDES AND SIALOGLYCOPROTEINS IN NORMAL AND DENERVATED RAT DIAPHRAGM MUSCLE

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dc.contributor.authorINESTROSA, NC
dc.contributor.authorFERNANDEZ, HL
dc.date.accessioned2025-01-23T19:44:10Z
dc.date.available2025-01-23T19:44:10Z
dc.date.issued1982
dc.description.abstractGanglioside- and glycoprotein-bound sialic acid in endplate and non-endplate regions of rat diaphragm muscles were assessed 1-16 days after phrenic nerve transection. Sialic acid in glycoproteins (90% of total) and gangliosides (10% of total) from intact hemidiaphragms was distributed uniformly throughout endplate and nonendplate regions. After denervation, the total sialic acid per hemidiaphragm increased (days 1-4) and reached a maximum level (days 8-12) which remained constant (days 12-16). These sialic acid changes reflected increments in gangliosides (40% over control), which occurred simultaneously in endplate and non-endplate regions (days 1-8), and increments in sialoglycoproteins (70%-80% over control), which took place much earlier in endplate (days 1-8) than in nonendplate (days 8-14) regions. Maintenance of both sialoglycoproteins and gangliosides depends upon an intact innervation, probably through separate mechanisms involving different neurogenic factors.
dc.fuente.origenWOS
dc.identifier.eissn1097-4598
dc.identifier.issn0148-639X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99962
dc.identifier.wosidWOS:A1982MZ10700006
dc.issue.numero1
dc.language.isoen
dc.pagina.final38
dc.pagina.inicio33
dc.revistaMuscle & nerve
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGANGLIOSIDES AND SIALOGLYCOPROTEINS IN NORMAL AND DENERVATED RAT DIAPHRAGM MUSCLE
dc.typeartículo
dc.volumen5
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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