GANGLIOSIDES AND SIALOGLYCOPROTEINS IN NORMAL AND DENERVATED RAT DIAPHRAGM MUSCLE
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1982
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Abstract
Ganglioside- and glycoprotein-bound sialic acid in endplate and non-endplate regions of rat diaphragm muscles were assessed 1-16 days after phrenic nerve transection. Sialic acid in glycoproteins (90% of total) and gangliosides (10% of total) from intact hemidiaphragms was distributed uniformly throughout endplate and nonendplate regions. After denervation, the total sialic acid per hemidiaphragm increased (days 1-4) and reached a maximum level (days 8-12) which remained constant (days 12-16). These sialic acid changes reflected increments in gangliosides (40% over control), which occurred simultaneously in endplate and non-endplate regions (days 1-8), and increments in sialoglycoproteins (70%-80% over control), which took place much earlier in endplate (days 1-8) than in nonendplate (days 8-14) regions. Maintenance of both sialoglycoproteins and gangliosides depends upon an intact innervation, probably through separate mechanisms involving different neurogenic factors.