TOXIC EFFECT OF A PHOTOINDUCED TRYPTOPHAN-RIBOFLAVIN ADDUCT ON F9-TERATOCARCINOMA CELLS AND PREIMPLANTATION MOUSE EMBRYOS
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1988
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Abstract
Solutions containing L-tryptophan and riboflavin exposed to visible light, under N2 atmosphere, yield a tryptophan-riboflavin adduct, able to inhibit the growth of cultured F9 teratocarcinoma cells. This same effect was found in the presence of a mixture of the tryptophan photooxidation products and the adduct, when using solutions previously irradiated with visible light in an O2 atmosphere. A cytotoxic effect was also observed with embryos incubated in the presence of a tryptophan-riboflavin adduct, in the latter case necrosis and embryo development arrest occured.