PLACENTAL ALTERATIONS, INTRAUTERINE GROWTH-RETARDATION AND TERATOGENICITY ASSOCIATED WITH ENALAPRIL USE IN PREGNANT RATS

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dc.contributor.authorVALDES, G
dc.contributor.authorMARINOVIC, D
dc.contributor.authorFALCON, C
dc.contributor.authorCHUAQUI, R
dc.contributor.authorDUARTE, I
dc.date.accessioned2025-01-23T19:22:25Z
dc.date.available2025-01-23T19:22:25Z
dc.date.issued1992
dc.description.abstractEnalapril (15 mg/kg/day p.o.) was given to 11 pregnant rats from day 1 to 9 (E1-9) and to 11 rats from day 10 to 20 (E10-20) of pregnancy; 12 rats were the control group. Fifteen animals were sacrificed on day 20 of pregnancy and 19 were allowed to progress into partum. Placentas were smaller in E10-20 rats (-15%, p < 0.05) and had a simple hypocellular cordonal structure; in E1-9 animals the predominant pattern was a combination of complex and simple structure. At day 20 the fetuses in the treated groups were smaller than the controls (-5% in E1-9 and -16% in E10-20, p < 0.05); differences disappeared on the 13th day postpartum. Two fetuses from treated mothers presented incomplete skull ossification. We believe this report adds arguments to preclude converting enzyme inhibitors in pregnancy.
dc.fuente.origenWOS
dc.identifier.issn0006-3126
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99033
dc.identifier.wosidWOS:A1992HK29600008
dc.issue.numero2
dc.language.isoen
dc.pagina.final130
dc.pagina.inicio124
dc.revistaBiology of the neonate
dc.rightsacceso restringido
dc.subjectPREGNANCY
dc.subjectCONVERTING ENZYME INHIBITORS
dc.subjectINTRAUTERINE GROWTH RETARDATION
dc.subjectTERATOGENICITY
dc.subjectPLACENTA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePLACENTAL ALTERATIONS, INTRAUTERINE GROWTH-RETARDATION AND TERATOGENICITY ASSOCIATED WITH ENALAPRIL USE IN PREGNANT RATS
dc.typeartículo
dc.volumen61
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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