PLACENTAL ALTERATIONS, INTRAUTERINE GROWTH-RETARDATION AND TERATOGENICITY ASSOCIATED WITH ENALAPRIL USE IN PREGNANT RATS
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Date
1992
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Abstract
Enalapril (15 mg/kg/day p.o.) was given to 11 pregnant rats from day 1 to 9 (E1-9) and to 11 rats from day 10 to 20 (E10-20) of pregnancy; 12 rats were the control group. Fifteen animals were sacrificed on day 20 of pregnancy and 19 were allowed to progress into partum. Placentas were smaller in E10-20 rats (-15%, p < 0.05) and had a simple hypocellular cordonal structure; in E1-9 animals the predominant pattern was a combination of complex and simple structure. At day 20 the fetuses in the treated groups were smaller than the controls (-5% in E1-9 and -16% in E10-20, p < 0.05); differences disappeared on the 13th day postpartum. Two fetuses from treated mothers presented incomplete skull ossification. We believe this report adds arguments to preclude converting enzyme inhibitors in pregnancy.
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Keywords
PREGNANCY, CONVERTING ENZYME INHIBITORS, INTRAUTERINE GROWTH RETARDATION, TERATOGENICITY, PLACENTA