IS THERE A CORRESPONDENCE BETWEEN HALF-LIVES OF MOTOR ENDPLATE ACETYLCHOLINESTERASE AND JUNCTIONAL ACETYLCHOLINE RECEPTORS

INESTROSA, NC; FERNANDEZ, HL

IS THERE A CORRESPONDENCE BETWEEN HALF-LIVES OF MOTOR ENDPLATE ACETYLCHOLINESTERASE AND JUNCTIONAL ACETYLCHOLINE RECEPTORS

Date

1977

Authors

INESTROSA, NC

FERNANDEZ, HL

Abstract

To study the turnover rate of motor endplate acetylcholinesterase (AChE), we have treated the hypoglossal nerve [rat] with 10 mM colchicine, a drug that produced a reversible decrease of AChE from geniohyoid muscle endplates. The return of AChE to the normal steady-state level was used to calculate an AChE half-life of 4.6 days. This value was very close to that obtained for the half-life of junctional acetylcholine receptors (AChR). Both macromolecules seem to have the same turnover rate.