Synthesis of Novel Quin[1,2-b]Acridines: <i>In Vitro</i> Cytotoxicity and Molecular Docking Studies

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dc.contributor.authorSatheeshkumar, Rajendran
dc.contributor.authorEdatt, Lincy
dc.contributor.authorMuthusankar, Aathi
dc.contributor.authorKumar, V. B. Sameer
dc.contributor.authorPrasad, Karnam Jayarampillai Rajendra
dc.date.accessioned2025-01-20T23:56:30Z
dc.date.available2025-01-20T23:56:30Z
dc.date.issued2021
dc.description.abstractAn attempted synthesis of 5-aryl-6,7-dihydrodibenzo[b,j][1,10]phenanthroline derivatives from 2,3-dihydroacridin-4(1H)-ones with 2-aminocarboxylic acid derivatives in presence of phosphorus oxychloride at 130C yielded a novel class of quin[1,2-b]acridine derivatives. The newly synthesized compounds showed a better cytotoxic activity against HeLa and MCF-7 cell lines during the structure-activity relationship (SAR) studies. To discover with the interactions of these molecules, we carried out molecular docking studies using the human protein kinase CK2 inhibitors. The molecular interaction results provided a number of elegant information for the outlook design of more potent inhibitors.
dc.fuente.origenWOS
dc.identifier.doi10.1080/10406638.2019.1689515
dc.identifier.eissn1563-5333
dc.identifier.issn1040-6638
dc.identifier.urihttps://doi.org/10.1080/10406638.2019.1689515
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95158
dc.identifier.wosidWOS:000498368600001
dc.issue.numero8
dc.language.isoen
dc.pagina.final1645
dc.pagina.inicio1631
dc.revistaPolycyclic aromatic compounds
dc.rightsacceso restringido
dc.subjectCytotoxic activity
dc.subject2
dc.subject3-Dihydroacridin-4(1H)-ones
dc.subjectMolecular docking studies
dc.subjectQuin[1
dc.subject2-b]acridines
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSynthesis of Novel Quin[1,2-b]Acridines: <i>In Vitro</i> Cytotoxicity and Molecular Docking Studies
dc.typeartículo
dc.volumen41
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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