Synthesis of Novel Quin[1,2-b]Acridines: <i>In Vitro</i> Cytotoxicity and Molecular Docking Studies
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Date
2021
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Abstract
An attempted synthesis of 5-aryl-6,7-dihydrodibenzo[b,j][1,10]phenanthroline derivatives from 2,3-dihydroacridin-4(1H)-ones with 2-aminocarboxylic acid derivatives in presence of phosphorus oxychloride at 130C yielded a novel class of quin[1,2-b]acridine derivatives. The newly synthesized compounds showed a better cytotoxic activity against HeLa and MCF-7 cell lines during the structure-activity relationship (SAR) studies. To discover with the interactions of these molecules, we carried out molecular docking studies using the human protein kinase CK2 inhibitors. The molecular interaction results provided a number of elegant information for the outlook design of more potent inhibitors.
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Keywords
Cytotoxic activity, 2, 3-Dihydroacridin-4(1H)-ones, Molecular docking studies, Quin[1, 2-b]acridines