Antibiotic treatment of patients with term premature rupture of membranes

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dc.contributor.authorOvalle, A
dc.contributor.authorGómez, R
dc.contributor.authorMartinez, MA
dc.contributor.authorGiglio, MS
dc.contributor.authorBianchi, R
dc.contributor.authorDiaz, L
dc.contributor.authorSáez, J
dc.contributor.authorPoblete, JP
dc.contributor.authorRomero, R
dc.date.accessioned2025-01-21T01:32:24Z
dc.date.available2025-01-21T01:32:24Z
dc.date.issued1998
dc.description.abstractBackground/objective Subclinical microbial invasion of the amniotic cavity in patients with premature rupture of membranes (PROM) at term occurs in 34% of cases and is a risk factor for puerperal endometritis. This study was conducted to determine whether antibiotic administration to women with PROM at term could reduce the rate of infection-related morbidity.
dc.description.abstractStudy design Between August 1990 and December 1993, patients with term PROM were randomly allocated to receive either cefuroxime-clindamicin or placebo.
dc.description.abstractResults Fifty-five patients received intravenous antibiotics and 50 patients received placebo. Patients allocated to the antibiotic group had a lower incidence of maternal infection-related morbidity (clinical chorioamnionitis and puerperal endometritis) than patients who received placebo (1.8% (1/55) vs. 16% (8/50), respectively, p < 0.05). No significant differences were found in other maternal and neonatal outcomes between the two groups.
dc.description.abstractConclusion Administration of antibiotics to patients with PROM at term results in a significant reduction in the rate of maternal infection-related morbidity.
dc.fuente.origenWOS
dc.identifier.issn1359-8635
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97255
dc.identifier.wosidWOS:000078273000016
dc.issue.numero6
dc.language.isoen
dc.pagina.final606
dc.pagina.inicio599
dc.revistaPrenatal and neonatal medicine
dc.rightsacceso restringido
dc.subjectrupture of membranes
dc.subjectintra-amniotic infection
dc.subjectchorioamnionitis
dc.subjectpuerperal endometritis
dc.subjectantibiotics
dc.subjectrandomized clinical trial
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleAntibiotic treatment of patients with term premature rupture of membranes
dc.typeartículo
dc.volumen3
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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