Antibiotic treatment of patients with term premature rupture of membranes
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Date
1998
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Abstract
Background/objective Subclinical microbial invasion of the amniotic cavity in patients with premature rupture of membranes (PROM) at term occurs in 34% of cases and is a risk factor for puerperal endometritis. This study was conducted to determine whether antibiotic administration to women with PROM at term could reduce the rate of infection-related morbidity.
Study design Between August 1990 and December 1993, patients with term PROM were randomly allocated to receive either cefuroxime-clindamicin or placebo.
Results Fifty-five patients received intravenous antibiotics and 50 patients received placebo. Patients allocated to the antibiotic group had a lower incidence of maternal infection-related morbidity (clinical chorioamnionitis and puerperal endometritis) than patients who received placebo (1.8% (1/55) vs. 16% (8/50), respectively, p < 0.05). No significant differences were found in other maternal and neonatal outcomes between the two groups.
Conclusion Administration of antibiotics to patients with PROM at term results in a significant reduction in the rate of maternal infection-related morbidity.
Study design Between August 1990 and December 1993, patients with term PROM were randomly allocated to receive either cefuroxime-clindamicin or placebo.
Results Fifty-five patients received intravenous antibiotics and 50 patients received placebo. Patients allocated to the antibiotic group had a lower incidence of maternal infection-related morbidity (clinical chorioamnionitis and puerperal endometritis) than patients who received placebo (1.8% (1/55) vs. 16% (8/50), respectively, p < 0.05). No significant differences were found in other maternal and neonatal outcomes between the two groups.
Conclusion Administration of antibiotics to patients with PROM at term results in a significant reduction in the rate of maternal infection-related morbidity.
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Keywords
rupture of membranes, intra-amniotic infection, chorioamnionitis, puerperal endometritis, antibiotics, randomized clinical trial