INHIBITION IN CAROTID-BODY CHEMORECEPTORS MEDIATED BY D-2 DOPAMINOCEPTORS - ANTAGONISM BY BENZAMIDES

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dc.contributor.authorZAPATA, P
dc.contributor.authorSERANI, A
dc.contributor.authorLAVADOS, M
dc.date.accessioned2025-01-23T19:43:55Z
dc.date.available2025-01-23T19:43:55Z
dc.date.issued1983
dc.description.abstractInhibition of chemosensory nerve impulses in the cat is evoked by dopamine (DA) applied to carotid body chemoreceptors. Pharmacological characterization of the dopaminoceptors involved in this action was determined through their blockade with benzamides, selective antagonists of D-2 receptors. Both metoclopramide and sulpiride were effective blockers of DA-induced chemosensory inhibition. Both drugs induced an immmediate increase in the frequency of carotid nerve chemosensory impulses, suggesting the presence of previous tonic inhibition of chemoreceptor discharges by endogenous DA release from glomus cells.
dc.fuente.origenWOS
dc.identifier.eissn1872-7972
dc.identifier.issn0304-3940
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99867
dc.identifier.wosidWOS:A1983RZ79100012
dc.issue.numero2
dc.language.isoen
dc.pagina.final184
dc.pagina.inicio179
dc.revistaNeuroscience letters
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleINHIBITION IN CAROTID-BODY CHEMORECEPTORS MEDIATED BY D-2 DOPAMINOCEPTORS - ANTAGONISM BY BENZAMIDES
dc.typeartículo
dc.volumen42
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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