INHIBITION IN CAROTID-BODY CHEMORECEPTORS MEDIATED BY D-2 DOPAMINOCEPTORS - ANTAGONISM BY BENZAMIDES
No Thumbnail Available
Date
1983
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Inhibition of chemosensory nerve impulses in the cat is evoked by dopamine (DA) applied to carotid body chemoreceptors. Pharmacological characterization of the dopaminoceptors involved in this action was determined through their blockade with benzamides, selective antagonists of D-2 receptors. Both metoclopramide and sulpiride were effective blockers of DA-induced chemosensory inhibition. Both drugs induced an immmediate increase in the frequency of carotid nerve chemosensory impulses, suggesting the presence of previous tonic inhibition of chemoreceptor discharges by endogenous DA release from glomus cells.