Global, Regional, and National Disparities in the Burden of Acute Pancreatitis and Alcohol-Related Pancreatitis From 2000 to 2021
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Date
2025
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Abstract
Objective: To provide updated estimates of the global burden of acute pancreatitis (AP) as a majorcause of hospital admissions for gastrointestinal diseases, which has a varied burden worldwide.Methods: The Global Burden of Disease Study 2021 was assessed to retrieve incidence, death, andage-standardized incidence (ASIR) and death (ASDR) rates for AP from 2000 to 2021. We alsofocused on the ASDR for AP from alcohol use.Results: In 2021, the burden of AP accounted for 2.75 million cases with 122,420 deaths. EasternEurope exhibited the highest burden. From 2000 to 2021, there was a decline in ASIR (annualpercentage change [APC], —0.25%; 95% CI, —0.26% to —0.25%) and ASDR (APC, —0.75%; 95% CI,—0.90% to —0.59%). However, ASIR increased in low (APC, 0.06%; 95% CI, 0.05 to 0.06%), lowmiddle (APC, 0.19%; 95% CI, 0.18% to 0.20%), and middle (APC, 0.14%; 95% CI, 0.13% to0.15%) sociodemographic index countries. Globally, 65 of 204 countries have undergone an increasein ASIR from AP. The ASDR for alcohol-related AP decreased worldwide but increased in low (APC,1.48%; 95% CI, 1.37% to 1.59%), low-middle (APC, 1.63%; 95% CI, 1.36% to 1.90%), and middle(APC, 0.75%; 95% CI, 0.54% to 0.96%) sociodemographic index countries.Conclusion: A substantial increase in the global burden of AP affected one-third of countries,particularly those with lower socioeconomic development, necessitating efforts to mitigate its riskfactors, one of which is alcohol consumption