UPTAKE AND RELEASE OF MANGANESE BY RAT STRIATAL SLICES

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dc.contributor.authorDANIELS, AJ
dc.contributor.authorGYSLING, K
dc.contributor.authorABARCA, J
dc.date.accessioned2025-01-23T19:44:16Z
dc.date.available2025-01-23T19:44:16Z
dc.date.issued1981
dc.description.abstractAccumulation of Mn in rat corpus striatum slices was non-saturable, although relatively strongly temperature dependent and inhibited by 2,4-dinitrophenol (2,4-DNP). Once incorporated, the metal ion was released by K+ (55 mM) depolarization in the presence of Ca ions, following a time course of efflux parallel to that of [3H]dopamine ([3H]DA). The release of the metal ion was not induced by tyramine. [3H]DA release was also induced by low concentrations of MnCl2. The possibility exists that these findings may be related in some way to the functional deficiency of the nigro-striatal dopaminergic system found after Mn poisoning.
dc.fuente.origenWOS
dc.identifier.eissn1873-2968
dc.identifier.issn0006-2952
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99993
dc.identifier.wosidWOS:A1981LW36600019
dc.issue.numero13
dc.language.isoen
dc.pagina.final1837
dc.pagina.inicio1833
dc.revistaBiochemical pharmacology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleUPTAKE AND RELEASE OF MANGANESE BY RAT STRIATAL SLICES
dc.typeartículo
dc.volumen30
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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