UPTAKE AND RELEASE OF MANGANESE BY RAT STRIATAL SLICES
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1981
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Abstract
Accumulation of Mn in rat corpus striatum slices was non-saturable, although relatively strongly temperature dependent and inhibited by 2,4-dinitrophenol (2,4-DNP). Once incorporated, the metal ion was released by K+ (55 mM) depolarization in the presence of Ca ions, following a time course of efflux parallel to that of [3H]dopamine ([3H]DA). The release of the metal ion was not induced by tyramine. [3H]DA release was also induced by low concentrations of MnCl2. The possibility exists that these findings may be related in some way to the functional deficiency of the nigro-striatal dopaminergic system found after Mn poisoning.