Metabolic effects on lung parenchyma of chronic hypoxia secondary to its extrinsic compression in an animal model of congenital diaphragmatic hernia

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dc.catalogadorvdr
dc.contributor.advisorCarvajal C., Jorge A.
dc.contributor.authorFerrer Márquez, Fernando Andrés
dc.contributor.otherPontificia Universidad Católica de Chile. Escuela de Medicina
dc.date2025-09-30
dc.date.accessioned2025-05-30T18:59:34Z
dc.date.issued2024
dc.date.updated2025-05-27T13:00:42Z
dc.descriptionTESIS EMBARGADA POR EL ALUMNO HASTA EL 30 DE SEPTIEMBRE DE 2025
dc.descriptionTesis (Doctor in Medical Sciences)--Pontificia Universidad de Chile, 2024
dc.description.abstractCongenital diaphragmatic hernia (CDH) occurs as a consequence of abnormal development of the transverse septum and incomplete closure of the pleuroperitoneal canals that occurs between the 6th and 10th week of gestation, resulting in herniation of the abdominal viscera through the diaphragmatic defect. The incidence of CDH is 1.93/10.000 births in North America, with an overall 45.89% mortality in the first year of life. In other latitudes of the world, it is similar, with a prevalence, for example, in Canada of 3.38 per 10,000 and in Chile of 2.1 per 10,000 live births, with a mortality rate in the first year of life between 45 and 65%. Despite all the advances of the last 20 years in maternal-fetal medicine, neonatology, and pediatric surgery, mortality remains high at 45-65% in CDH patients. In the prenatal period, timely diagnosis and the attempt to classify fetuses with CDH according to their risk of death and prognosis have been a constant challenge in maternalfetal medicine (MFM). Even advanced ventilatory and circulatory support techniques, such as extracorporeal membrane oxygenation (ECMO), used in the neonatal period have not significantly influenced the mortality rate of CDH.
dc.description.version2025-09-30
dc.fechaingreso.objetodigital2025-05-30
dc.format.extent86 páginas
dc.fuente.origenSRIA
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104540
dc.information.autorucEscuela de Medicina; Carvajal C., Jorge A.; 0000-0001-6875-7825; 3345
dc.information.autorucEscuela de Medicina; Ferrer Márquez, Fernando Andrés; 0000-0002-0738-8621; 227733
dc.language.isoen
dc.nota.accesoContenido completo
dc.rightsacceso embargado
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMetabolic effects on lung parenchyma of chronic hypoxia secondary to its extrinsic compression in an animal model of congenital diaphragmatic hernia
dc.typetesis doctoral
sipa.codpersvinculados3345
sipa.codpersvinculados227733
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