Metabolic effects on lung parenchyma of chronic hypoxia secondary to its extrinsic compression in an animal model of congenital diaphragmatic hernia
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Date
2024
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Abstract
Congenital diaphragmatic hernia (CDH) occurs as a consequence of abnormal development of the transverse septum and incomplete closure of the pleuroperitoneal canals that occurs between the 6th and 10th week of gestation, resulting in herniation of the abdominal viscera through the diaphragmatic defect. The incidence of CDH is 1.93/10.000 births in North America, with an overall 45.89% mortality in the first year of life. In other latitudes of the world, it is similar, with a prevalence, for example, in Canada of 3.38 per 10,000 and in Chile of 2.1 per 10,000 live births, with a mortality rate in the first year of life between 45 and 65%. Despite all the advances of the last 20 years in maternal-fetal medicine, neonatology, and pediatric surgery, mortality remains high at 45-65% in CDH patients. In the prenatal period, timely diagnosis and the attempt to classify fetuses with CDH according to their risk of death and prognosis have been a constant challenge in maternalfetal medicine (MFM). Even advanced ventilatory and circulatory support techniques, such as extracorporeal membrane oxygenation (ECMO), used in the neonatal period have not significantly influenced the mortality rate of CDH.
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TESIS EMBARGADA POR EL ALUMNO HASTA EL 30 DE SEPTIEMBRE DE 2025
Tesis (Doctor in Medical Sciences)--Pontificia Universidad de Chile, 2024
Tesis (Doctor in Medical Sciences)--Pontificia Universidad de Chile, 2024