STRUCTURE OF THE EUKARYOTIC GENOME - A UNIQUE PSEUDOGENE LACKING INTRONS AND POLY-A TAIL AS A MEMBER OF THE HUMAN BETA-TUBULIN GENE FAMILY

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dc.contributor.authorPICHUANTES, S
dc.contributor.authorMEDINA, A
dc.contributor.authorBELL, G
dc.contributor.authorGOMEZ, I
dc.contributor.authorVALENZUELA, P
dc.contributor.authorBULL, P
dc.contributor.authorVENEGAS, A
dc.date.accessioned2025-01-23T19:44:05Z
dc.date.available2025-01-23T19:44:05Z
dc.date.issued1982
dc.description.abstractFrom a human gene bank constructed in the vector phage Charon 4A, 14 clones carrying complementary sequences to .alpha. and .beta. tubulin chicken c[complementary]DNA were isolated. A preliminary structural analysis of some of the .beta. clones, based on restriction digests followed by Southern hybridization, allowed us to select clone .beta.9 as the one containing a functional gene. After further analysis this clone was proved to contain a pseudogene. The coding sequence is altered by 4 stop codons, 6 short delections and 2 1-base insertions. These changes prevent any correct translation. The pseudogene seems to preserve some vestigial control regions and does not contain introns. No in vitro RNA synthesis directed by this clone was detected.
dc.fuente.origenWOS
dc.identifier.issn0004-0533
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99938
dc.identifier.wosidWOS:A1982PY94500023
dc.issue.numero3-4
dc.language.isoen
dc.pagina.final394
dc.pagina.inicio381
dc.revistaArchivos de biologia y medicina experimentales
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSTRUCTURE OF THE EUKARYOTIC GENOME - A UNIQUE PSEUDOGENE LACKING INTRONS AND POLY-A TAIL AS A MEMBER OF THE HUMAN BETA-TUBULIN GENE FAMILY
dc.typeartículo
dc.volumen15
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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