ANTAGONISM OF DOPAMINE-INDUCED CHEMOSENSORY INHIBITION BY ERGOT ALKALOIDS
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1978
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Abstract
Intracarotid and i.v. injections of ergometrine, methylergometrine, ergotamine, dihydroergotamine, dihydroergotoxine and 2-Br-.alpha.-ergocryptine depressed the frequency of chemosensory impulses, recorded from the carotid nerve of anesthetized cats. After administration of ergot alkaloids, dopamine-induced inhibition of chemosensory activity was blocked; this effect was not associated with blocking of .alpha.-adrenoceptors for ergometrine, methylergometrine, ergotamine and 2-Br-.alpha.-ergocryptine, but it coincided with .alpha.-adrenergic antagonism for dihydroergotamine and dihydroergotoxine. Ergot alkaloids can act on carotid body chemoreceptors as dopamine analogs and antagonists.