Inactivation of Glutamine Synthetase-Coding Gene <i>glnA</i> Increases Susceptibility to Quinolones Through Increasing Outer Membrane Protein F in <i>Salmonella enterica</i> Serovar Typhi

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dc.contributor.authorMillanao, Ana R.
dc.contributor.authorMora, Aracely Y.
dc.contributor.authorSaavedra, Claudia P.
dc.contributor.authorVillagra, Nicolas A.
dc.contributor.authorMora, Guido C.
dc.contributor.authorHidalgo, Alejandro A.
dc.date.accessioned2025-01-23T19:53:41Z
dc.date.available2025-01-23T19:53:41Z
dc.date.issued2020
dc.description.abstractCiprofloxacin is the choice treatment for infections caused by Salmonella Typhi, however, reduced susceptibility to ciprofloxacin has been reported for this pathogen. Considering the decreased approbation of new antimicrobials and the crisis of resistance, one strategy to combat this problem is to find new targets that enhances the antimicrobial activity for approved antimicrobials. In search of mutants with increased susceptibility to ciprofloxacin; 3,216 EZ-Tn5 transposon mutants of S. Typhi were screened. S. Typhi zxx
dc.fuente.origenWOS
dc.identifier.doi10.3389/fmicb.2020.00428
dc.identifier.issn1664-302X
dc.identifier.urihttps://doi.org/10.3389/fmicb.2020.00428
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100668
dc.identifier.wosidWOS:000523648600001
dc.language.isoen
dc.revistaFrontiers in microbiology
dc.rightsacceso restringido
dc.subjectglnA
dc.subjectciprofloxacin
dc.subjectOmpF
dc.subjectS
dc.subjectTyphi
dc.subjecttransposon
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleInactivation of Glutamine Synthetase-Coding Gene <i>glnA</i> Increases Susceptibility to Quinolones Through Increasing Outer Membrane Protein F in <i>Salmonella enterica</i> Serovar Typhi
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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