Inactivation of Glutamine Synthetase-Coding Gene <i>glnA</i> Increases Susceptibility to Quinolones Through Increasing Outer Membrane Protein F in <i>Salmonella enterica</i> Serovar Typhi
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Date
2020
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Abstract
Ciprofloxacin is the choice treatment for infections caused by Salmonella Typhi, however, reduced susceptibility to ciprofloxacin has been reported for this pathogen. Considering the decreased approbation of new antimicrobials and the crisis of resistance, one strategy to combat this problem is to find new targets that enhances the antimicrobial activity for approved antimicrobials. In search of mutants with increased susceptibility to ciprofloxacin; 3,216 EZ-Tn5 transposon mutants of S. Typhi were screened. S. Typhi zxx
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glnA, ciprofloxacin, OmpF, S, Typhi, transposon