Purinergic receptor antagonism reduces interictal discharges and rescues cognitive function in a mouse model of temporal lobe epilepsy

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dc.catalogadorcarga
dc.contributor.authorEspinosa, Nelson
dc.contributor.authorMartin-Suarez, Soraya
dc.contributor.authorLara-Vasquez, Ariel
dc.contributor.authorMontero, Trinidad
dc.contributor.authorMuro-Garcia, Teresa
dc.contributor.authorFernandez, German
dc.contributor.authorEncinas-Perez, Juan Manuel
dc.contributor.authorFuentealba, Pablo
dc.date.accessioned2025-11-15T10:30:11Z
dc.date.available2025-11-15T10:30:11Z
dc.date.issued2025
dc.description.abstractEpilepsy is one of the most prevalent neurological disorders globally. Current treatments mainly target neuronal activity, often overlooking the involvement of astrocytes and microglia in epilepsy's pathophysiology. Here, we explored the impact of purinergic receptors, predominantly found in glial tissue, on epileptiform activity. We used TNP-ATP, a potent purinergic receptor antagonist, and conducted experiments using a mouse model of mesial temporal lobe epilepsy to examine behavioral performance and neural activity patterns. Our findings reveal that although TNP-ATP treatment did not significantly impact motor function or anxiety levels, it reduced both the amplitude and rate of hippocampal interictal discharges. Such reduction also affected the synchrony of associated neuronal spiking. Additionally, cognitive function, particularly hippocampus-dependent spatial memory and prefrontal cortex-dependent executive control, were partially restored. Moreover, neuronal recordings showed increased phase coherence between the hippocampus and prefrontal cortex for both slow (theta) and fast (gamma) oscillations in treated animals, indicating strengthened neural coordination between cortical regions upon purinergic receptor antagonism. These results underscore the potential role of purinergic receptor antagonists in improving behavioral and cognitive performance in epilepsy, providing novel insight into the use of these pharmacological agents as a therapeutic approach.
dc.fuente.origenWOS
dc.identifier.doi10.3389/fnins.2025.1513135
dc.identifier.eissn1662-453X
dc.identifier.issn0378-1844
dc.identifier.scopusidSCOPUS_ID:85048043745
dc.identifier.urihttps://doi.org/10.3389/fnins.2025.1513135
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/107009
dc.identifier.wosidWOS:001469347500001
dc.information.autorucEscuela de Medicina; Fuentealba Durand, Pablo Jose; 0000-0002-9679-4612; 19184
dc.information.autorucEscuela de Medicina | Programa de Estudios Generales College; Lara Vásquez, Ariel Fernando; S/I; 127231
dc.information.autorucFacultad de Ciencias Biológicas; Trinidad Dayenu Montero Ossandon; S/I; 149727
dc.information.autorucNo Informado
dc.information.autorucNo Informado; Lara Vásquez, Ariel Fernando; S/I; 127231
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final312
dc.pagina.inicio304
dc.revistaFRONTIERS IN NEUROSCIENCE
dc.rightsregistro bibliográfico
dc.subjectpurinergic receptor
dc.subjecttemporal lobe epilepsy
dc.subjectinterictal discharges
dc.subjectcognitive dysfunction
dc.subjectcortical oscillation
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePurinergic receptor antagonism reduces interictal discharges and rescues cognitive function in a mouse model of temporal lobe epilepsy
dc.typeartículo
dc.volumen19
sipa.codpersvinculados19184
sipa.codpersvinculados127231
sipa.codpersvinculados149727
sipa.codpersvinculados127231
sipa.indexWOS
sipa.trazabilidadWOS-SCOPUS;2025-11-15
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