Tea Bags for Fmoc Solid-Phase Peptide Synthesis: An Example of Circular Economy

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dc.contributor.authorGuzman, Fanny
dc.contributor.authorGauna, Adriana
dc.contributor.authorRoman, Tanya
dc.contributor.authorLuna, Omar
dc.contributor.authorAlvarez, Claudio
dc.contributor.authorPareja-Barrueto, Claudia
dc.contributor.authorMercado, Luis
dc.contributor.authorAlbericio, Fernando
dc.contributor.authorCardenas, Constanza
dc.date.accessioned2025-01-20T22:09:42Z
dc.date.available2025-01-20T22:09:42Z
dc.date.issued2021
dc.description.abstractPeptide synthesis is an area with a wide field of application, from biomedicine to nanotechnology, that offers the option of simultaneously synthesizing a large number of sequences for the purpose of preliminary screening, which is a powerful tool. Nevertheless, standard protocols generate large volumes of solvent waste. Here, we present a protocol for the multiple Fmoc solid-phase peptide synthesis in tea bags, where reagent recycling steps are included. Fifty-two peptides with wide amino acid composition and seven to twenty amino acid residues in length were synthesized in less than three weeks. A clustering analysis was performed, grouping the peptides by physicochemical features. Although a relationship between the overall yield and the physicochemical features of the sequences was not established, the process showed good performance despite sequence diversity. The recycling system allowed to reduce N, N-dimethylformamide usage by 25-30% and reduce the deprotection reagent usage by 50%. This protocol has been optimized for the simultaneous synthesis of a large number of peptide sequences. Additionally, a reagent recycling system was included in the procedure, which turns the process into a framework of circular economy, without affecting the quality of the products obtained.
dc.fuente.origenWOS
dc.identifier.doi10.3390/molecules26165035
dc.identifier.eissn1420-3049
dc.identifier.urihttps://doi.org/10.3390/molecules26165035
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94343
dc.identifier.wosidWOS:000689912800001
dc.issue.numero16
dc.language.isoen
dc.revistaMolecules
dc.rightsacceso restringido
dc.subjectsimultaneous synthesis
dc.subjectgreen chemistry
dc.subjectreagents' recycling
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTea Bags for Fmoc Solid-Phase Peptide Synthesis: An Example of Circular Economy
dc.typeartículo
dc.volumen26
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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