INHIBITORY EFFECT OF RENIN EXTRACTS UPON URINARY KALLIKREIN EXCRETION
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Date
1978
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Abstract
I.p. injections of 1-5 IU of renin purified extracts, obtained either from hog or rat kidneys, in hyperhydrated rats receiving distilled water or 0.4% NaCl (5% body wt) produce not only a striking increase in the Na excretion rate but a very significant decrease in kallikrein excretion as well. In the urine excreted in the 1st h after renin administration kallikrein practically disappeared in the urine; with higher doses the inhibitory effect was very marked and lasted up to 120 min. In the same rats under a 2nd hyperhydration, not associated with renin injection, kallikrein tends to return to control levels.