Prenatal caloric restriction adjusts the energy homeostasis and behavior in response to acute and chronic variations in food availability in adulthood

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dc.contributor.authorPena-Villalobos, Isaac
dc.contributor.authorOtarola, Fabiola A.
dc.contributor.authorArancibia, David
dc.contributor.authorSabat, Pablo
dc.contributor.authorPalma, Veronica
dc.date.accessioned2025-01-20T17:26:19Z
dc.date.available2025-01-20T17:26:19Z
dc.date.issued2023
dc.description.abstractFetal metabolic programming produced by unfavorable prenatal nutritional conditions leads to the development of a disorder called "thrifty phenotype", which is associated with pathologies such as diabetes and obesity in adulthood. However, from an ecophysiological approach, few studies have addressed the development of thrifty phenotypes in terms of energy. This might represent an adaptive advantage against caloric deficiency conditions extending into adulthood. The objective of this study is to investigate the potential adaptive value of the thrifty phenotype expression through prenatal programming in a rodent model experiencing varying dietary conditions in different temporal contexts. To fill this gap, adult males of Mus musculus (BALB/C) from two maternal pregnancy groups were analyzed: control (ad libitum feeding) and caloric restriction from day 10 of gestation (70% restriction). Adult offspring of these groups were split further for two experiments: acute food deprivation and chronic caloric restriction at 60%. The acute food deprivation was performed for 24, 48 or 72 h while the caloric restriction regime was sustained for 20 days. For each experiment, morphological variables, such as body and organ mass, and gene expression related to lipid and carbohydrate metabolism from the liver and brain, were evaluated. In chronic caloric restriction, behavioral tests (open-field test and home-cage behavior) were performed. Our results indicate that under acute deprivation, the liver mass and triglyceride content remained unchanged in individuals subjected to prenatal restriction, in contrast to the reduction experienced by the control group. The latter is associated with the expression of the key genes involved in energy homeostasis (Pepck, Ppar alpha/Ppar gamma), indicating a differential use of nutritional resources. In addition, thrifty animals, subjected to chronic caloric restriction, showed a severe reduction in locomotor and gluconeogenic activity, which is consistent with the regulatory role of Sirt1 and its downstream targets Mao and Pepck. Our results reveal that prenatal caloric restriction translates into a sparing metabolism in response to acute and chronic lack of food in adulthood.
dc.description.funderWe thank Catalina B. Muoz- Pacheco for her assistance in the measurement of triglyceride levels.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s00360-023-01520-6
dc.identifier.eissn1432-136X
dc.identifier.issn0174-1578
dc.identifier.urihttps://doi.org/10.1007/s00360-023-01520-6
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91552
dc.identifier.wosidWOS:001094723200001
dc.issue.numero6
dc.language.isoen
dc.pagina.final688
dc.pagina.inicio677
dc.revistaJournal of comparative physiology b-biochemical systems and environmental physiology
dc.rightsacceso restringido
dc.subjectGluconeogenesis
dc.subjectInanition
dc.subjectFood deprivation
dc.subjectPerinatal feeding
dc.subjectPredictive adaptive hypothesis
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePrenatal caloric restriction adjusts the energy homeostasis and behavior in response to acute and chronic variations in food availability in adulthood
dc.typeartículo
dc.volumen193
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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