Validation of the RCOphth and UKEGS glaucoma risk stratification tool 'GLAUC-STRAT-fast'

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dc.contributor.authorKonstantakopoulou, Evgenia
dc.contributor.authorKastner, Alan
dc.contributor.authorGazzard, Gus
dc.contributor.authorJayaram, Hari
dc.date.accessioned2025-01-20T20:21:40Z
dc.date.available2025-01-20T20:21:40Z
dc.date.issued2023
dc.description.abstractBackground/aims The aim of this study was to validate the Glaucoma Risk Stratification Tool (GLAUC-STRAT-fast) currently recommended by the Royal College of Ophthalmologists for the risk stratification of patients with glaucoma in the UK National Health Service Hospital Eye Service.
dc.description.abstractMethods GLAUC-STRAT fast was applied to the LiGHT trial participants by risk-stratifying the worse eye of each patient at baseline and after 3 years of treatment. Metrics of disease severity or treatment intensity used for the validation were: increased number of monitoring visits or treatment escalations; needing a trabeculectomy; a reduction of >2 dB in visual field mean deviation (VF MD) during the monitoring period; identification of rapid VF loss on total (TD) and/or pattern deviation (PD). The proportion of eyes within each baseline stratum for each of the above markers was compared against the other strata, using a chi(2) test for proportions.
dc.description.abstractResults There was an association between the baseline stratification and the number of treatment escalations needed to maintain the eye-specific target intraocular pressure (p=0.001), the number of visits needed throughout the 3-year follow-up period (p=0.001), the need for trabeculectomy (p<0.001) and absolute loss of MD over the course of the monitoring period (p<0.001). The rate of VF progression was not associated with baseline risk stratification for TD or PD progression (p >= 0.007, with Bonferroni correction).
dc.description.abstractConclusion The GLAUC-STRAT fast tool is a useful tool for risk stratifying eyes with ocular hypertension or open angle glaucoma. Further research is needed to confirm and validate its applicability to more advanced glaucomas and generalisability to dinical use.
dc.description.funderMoorfields Eye Charity
dc.fuente.origenWOS
dc.identifier.doi10.1136/bjophthalmol-2021-320968
dc.identifier.eissn1468-2079
dc.identifier.issn0007-1161
dc.identifier.urihttps://doi.org/10.1136/bjophthalmol-2021-320968
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92638
dc.identifier.wosidWOS:000793332300001
dc.issue.numero9
dc.language.isoen
dc.pagina.final1263
dc.pagina.inicio1258
dc.revistaBritish journal of ophthalmology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleValidation of the RCOphth and UKEGS glaucoma risk stratification tool 'GLAUC-STRAT-fast'
dc.typeartículo
dc.volumen107
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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