The Combination of RET, BRAF and Demographic Data Identifies Subsets of Patients with Aggressive Papillary Thyroid Cancer

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dc.contributor.authorMartinez, Jose R. W.
dc.contributor.authorVargas-Salas, Sergio
dc.contributor.authorUrra Gamboa, Soledad
dc.contributor.authorMunoz, Estefania
dc.contributor.authorMiguel Dominguez, Jose
dc.contributor.authorLeon, Augusto
dc.contributor.authorDroppelmann, Nicolas
dc.contributor.authorSolar, Antonieta
dc.contributor.authorZafereo, Mark
dc.contributor.authorHolsinger, F. Christopher
dc.contributor.authorGonzalez, Hernan E.
dc.date.accessioned2025-01-23T21:14:05Z
dc.date.available2025-01-23T21:14:05Z
dc.date.issued2019
dc.description.abstractThe use of BRAFV600E and RET/PTC1 as biomarkers to guide the extent of surgery in patients with papillary thyroid cancer (PTC) remains controversial. We assessed the combined use of demographic data (sex and age) with mRNA expression levels and/or mutational status (BRAFV600E and RET/PTC1) to identify potential subsets of patients with aggressive histopathological features (lymph node metastases and extrathyroidal extension). In a cohort of 126 consecutive patients, BRAFV600E and RET/PTC1 mutations were found in 52 and 18%, respectively. By conditional bivariate analysis (CBVA), a high activity' profile of BRAF (BRAFV600E positive or high expression) and low activity' profile of RET (RET/PTC1 negative or low expression) was associated with extrathyroidal extension (ETE) (OR 4.48). Alternatively, a high activity' profile of RET (RET/PTC1 positive or high expression) and low activity' profile of BRAF (BRAFV600E negative or low expression) were associated with lymph node metastasis (LNM) (OR 12.80). Furthermore, in patients younger than 55years, a low expression of BRAF was associated with LNM (OR 17.65) and the presence of BRAFV600E mutation was associated with ETE (OR 2.76). Our results suggest that the analysis of demographic and molecular variables by CBVA could contribute to identify subsets of patients with aggressive histopathologic features, providing a potential guide to personalised surgical management of PTC.
dc.description.funderBiomedical Research Consortium (BMRC)
dc.fuente.origenWOS
dc.identifier.doi10.1007/s12672-019-0359-8
dc.identifier.eissn1868-8500
dc.identifier.issn1868-8497
dc.identifier.urihttps://doi.org/10.1007/s12672-019-0359-8
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101017
dc.identifier.wosidWOS:000469509500006
dc.issue.numero2-3
dc.language.isoen
dc.pagina.final106
dc.pagina.inicio97
dc.revistaHormones & cancer
dc.rightsacceso restringido
dc.subjectPapillary thyroid cancer
dc.subjectBRAF V600E
dc.subjectRET
dc.subjectPTC1
dc.subjectLymph node metastasis
dc.subjectExtrathyroidal extension
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe Combination of RET, BRAF and Demographic Data Identifies Subsets of Patients with Aggressive Papillary Thyroid Cancer
dc.typeartículo
dc.volumen10
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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