Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood

Simple item page
dc.contributor.authorVerdolini, Norma
dc.contributor.authorBorras, Roger
dc.contributor.authorSparacino, Giulio
dc.contributor.authorGarriga, Marina
dc.contributor.authorSague-Vilavella, Maria
dc.contributor.authorMadero, Santiago
dc.contributor.authorPalacios-Garran, Roberto
dc.contributor.authorSerra, Maria
dc.contributor.authorForte, Maria Florencia
dc.contributor.authorSalagre, Estela
dc.contributor.authorAedo, Alberto
dc.contributor.authorSalgado-Pineda, Pilar
dc.contributor.authorMontoro Salvatierra, Irene
dc.contributor.authorSanchez Gistau, Vanessa
dc.contributor.authorPomarol-Clotet, Edith
dc.contributor.authorRamos-Quiroga, Josep Antoni
dc.contributor.authorCarvalho, Andre F.
dc.contributor.authorGarcia-Rizo, Clemente
dc.contributor.authorUndurraga, Juan
dc.contributor.authorReinares, Maria
dc.contributor.authorMartinez Aran, Anabel
dc.contributor.authorBernardo, Miguel
dc.contributor.authorVieta, Eduard
dc.contributor.authorPacchiarotti, Isabella
dc.contributor.authorAmoretti, Silvia
dc.date.accessioned2025-01-20T21:13:39Z
dc.date.available2025-01-20T21:13:39Z
dc.date.issued2022
dc.description.abstractObjective This study was aimed at identifying differences in the prodromal symptoms and their duration, risk factors and markers of vulnerability in patients presenting a first episode mania (FEM) or psychosis (FEP) with onset in late adolescence or adulthood in order to guide tailored treatment strategies. Methods Patients with a FEM or FEP underwent a clinical assessment. Prodromes were evaluated with the Bipolar Prodrome Symptom Scale-Retrospective (BPSS-R). Chi-squared tests were conducted to assess specific prodromal symptoms, risk factors or markers of vulnerability between groups. Significant prodromal symptoms were entered in a stepwise forward logistic regression model. The probabilities of a gradual versus rapid onset pattern of the prodromes were computed with logistic regression models. Results The total sample included 108 patients (FEM = 72, FEP = 36). Social isolation was associated with the prodromal stage of a FEP whilst Increased energy or goal-directed activity with the prodrome to a FEM. Physically slowed down presented the most gradual onset whilst Increased energy presented the most rapid. The presence of obstetric complications and difficulties in writing and reading during childhood were risk factors for FEP. As for markers of vulnerability, impairment in premorbid adjustment was characteristic of FEP patients. No specific risk factor or marker of vulnerability was identified for FEM. Conclusion Early characteristics differentiating FEP from FEM were identified. These findings might help shape early identification and preventive intervention programmes.
dc.fuente.origenWOS
dc.identifier.doi10.1111/acps.13415
dc.identifier.eissn1600-0447
dc.identifier.issn0001-690X
dc.identifier.urihttps://doi.org/10.1111/acps.13415
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93715
dc.identifier.wosidWOS:000760941000001
dc.issue.numero1
dc.language.isoen
dc.pagina.final50
dc.pagina.inicio36
dc.revistaActa psychiatrica scandinavica
dc.rightsacceso restringido
dc.subjectfirst episode mania
dc.subjectfirst episode psychosis
dc.subjectmarkers of vulnerability
dc.subjectprodromes
dc.subjectrisk factors
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleProdromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood
dc.typeartículo
dc.volumen146
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas