Cytokine profiles and the dynamic of gingivitis development in humans

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dc.contributor.authorLeite, Fabio R. M.
dc.contributor.authorNascimento, Gustavo G.
dc.contributor.authorMoller, Holger J.
dc.contributor.authorBelibasakis, Georgios N.
dc.contributor.authorBostanci, Nagihan
dc.contributor.authorSmith, Patricio C.
dc.contributor.authorLopez, Rodrigo
dc.date.accessioned2025-01-20T22:01:41Z
dc.date.available2025-01-20T22:01:41Z
dc.date.issued2022
dc.description.abstractAim To investigate the relationship between cytokine profiles and "fast" and "slow" patterns of gingival inflammation development. Materials and Methods Forty-two adults participated in an experimental gingivitis study, comprising a 2-week hygiene phase (clinical examination and professional cleaning); a 3-week induction phase (absence of oral hygiene); and a 2-week resolution phase (re-establishment of oral hygiene). Plaque and gingival inflammation scores were assessed. Interferon-gamma (IFN-gamma), interleukin (IL)-1 beta, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, and tumour necrosis factor-alpha (TNF-alpha) from gingival crevicular fluid were collected and measured by multiplex ELISA. Group-based-trajectory-modelling (GBTM) was used to model cytokine profiles over the induction phase. The effect of gingival inflammation on cytokine levels over time was estimated with mixed-effects modelling. Results GBTM analysis revealed two cytokine profiles, "non-organized response" (IL-4, IL-6, IL-8, IL-12, and IL-13) and "organized response" (IL-2, IL-10, and TNF-alpha). Among the "slow" responders, neither cytokine profile was associated with gingivitis. In contrast, a "fast" response was associated with a higher "non-organized response" factor (coef. 0.14) and a lower "organized response" factor (coef. -0.03). Conclusion A "fast" gingivitis development was associated with a higher "non-organized response" and a lower "organized response", which may elucidate the role of individual variability in gingivitis susceptibility.
dc.fuente.origenWOS
dc.identifier.doi10.1111/jcpe.13565
dc.identifier.eissn1600-051X
dc.identifier.issn0303-6979
dc.identifier.urihttps://doi.org/10.1111/jcpe.13565
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93872
dc.identifier.wosidWOS:000711730500001
dc.issue.numero1
dc.language.isoen
dc.pagina.final75
dc.pagina.inicio67
dc.revistaJournal of clinical periodontology
dc.rightsacceso restringido
dc.subjectgingival crevicular fluid
dc.subjectimmunity
dc.subjectinflammation
dc.subjectperiodontal diseases
dc.subjectstatistical factor analysis
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCytokine profiles and the dynamic of gingivitis development in humans
dc.typeartículo
dc.volumen49
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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