ThyroidPrint®: clinical utility for indeterminate thyroid cytology

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dc.article.number106217
dc.contributor.authorOlmos R.
dc.contributor.authorDominguez J.M.
dc.contributor.authorVargas-Salas S.
dc.contributor.authorMosso L.
dc.contributor.authorFardella C.E.
dc.contributor.authorGonzalez G.
dc.contributor.authorBaudrand R.
dc.contributor.authorGuarda F.
dc.contributor.authorValenzuela F.
dc.contributor.authorArteaga E.
dc.contributor.authorForenzano P.
dc.contributor.authorNilo F.
dc.contributor.authorLustig N.
dc.contributor.authorMartinez A.
dc.contributor.authorLopez J.M.
dc.contributor.authorCruz F.
dc.contributor.authorLoyola S.
dc.contributor.authorLeon A.
dc.contributor.authorDroppelmann N.
dc.contributor.authorMontero P.
dc.contributor.authorDominguez F.
dc.contributor.authorCamus M.
dc.contributor.authorSolar A.
dc.contributor.authorZoroquiain P.
dc.contributor.authorRoa J.C.
dc.contributor.authorMunoz E.
dc.contributor.authorBruce E.
dc.contributor.authorGajardo R.
dc.contributor.authorMiranda G.
dc.contributor.authorRiquelme F.
dc.contributor.authorMena N.
dc.contributor.authorGonzalez H.E.
dc.contributor.otherNCD Risk Factor Collaboration (NCD-RisC)
dc.date.accessioned2024-08-15T08:00:32Z
dc.date.available2024-08-15T08:00:32Z
dc.date.issued2023
dc.description.abstractMolecular testing contributes to improving the diagnosis of indeterminate thyroid nodules (ITNs). ThyroidPrint® is a ten-gene classifier aimed to rule out malignancy in ITN. Post-validation studies are necessary to determine the real-world clinical benefit of ThyroidPrint® in patients with ITN. A single-center, prospective, noninterventional clinical utility study was performed, analyzing the impact of ThyroidPrint® in the physicians' clinical decisions for ITN. Demographics, nodule characteristics, benign call rates (BCRs), and surgical outcomes were measured. Histopathological data were collected from surgical biopsies of resected nodules. Of 1272 fine-needle aspirations, 109 (8.6%) were Bethesda III and 135 (10.6%) were Bethesda IV. Molecular testing was performed in 155 of 244 ITN (63.5%), of which 104 were classified as benign (BCR of 67.1%). After a median follow-up of 15 months, 103 of 104 (99.0%) patients with a benign ThyroidPrint® remained under surveillance and one patient underwent surgery which was a follicular adenoma. Surgery was performed in all 51 patients with a suspicious for malignancy as per ThyroidPrint® result and in 56 patients who did not undergo testing, with a rate of malignancy of 70.6% and 32.1%, respectively. A higher BCR was observed in follicular lesion of undetermined significance (87%) compared to atypia of undetermined significance (58%) (P < 0.05). False-positive cases included four benign follicular nodules and six follicular and four oncocytic adenomas. Our results show that, physicians chose active surveillance instead of diagnostic surgery in all patients with a benign ThyroidPrint® result, reducing the need for diagnostic surgery in 67% of patients with preoperative diagnosis of ITN.
dc.description.funderANID through FONDECYT
dc.format.extent4 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1530/ERC-22-0409
dc.identifier.eissn1989-2209
dc.identifier.issn14796821
dc.identifier.pubmedid15543761
dc.identifier.scopusidSCOPUS_ID:85173580436
dc.identifier.urihttps://doi.org/10.1530/ERC-22-0409
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87485
dc.identifier.wosidWOS:001094084500002
dc.information.autorucFacultad de Medicina; Mosso Gomez, Lorena Montserrat; S/I; 88201
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final1059
dc.pagina.inicio1053
dc.relation.ispartof14th European Meeting on Hypertension, JUN 13-17, 2004, Paris, FRANCE
dc.revistaEndocrine-related cancer
dc.rightsacceso abierto
dc.subjectclinical utility
dc.subjectgenetic classifier
dc.subjectindeterminate thyroid cytology
dc.subject.ddc550
dc.subject.deweyCiencias de la tierraes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThyroidPrint®: clinical utility for indeterminate thyroid cytology
dc.typeartículo
dc.volumen30
sipa.codpersvinculados88201
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;15-08-2024
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