Donor selection in allogeneic stem cell transplantation

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dc.contributor.authorBarriga, Francisco
dc.contributor.authorLima, Alberto Cardoso Martins
dc.date.accessioned2025-01-20T16:08:01Z
dc.date.available2025-01-20T16:08:01Z
dc.date.issued2024
dc.description.abstractPurpose of reviewRecent progress in human leukocyte antigen (HLA) characterization, increased accrual of unrelated donors and cord blood units, and a new platform for haploidentical transplantation have resulted in the widespread availability of donors for allogeneic hematopoietic stem cell transplantation.Recent findingsAdvances in HLA typing have identified an increasing number of loci and alleles that are crucial for successful transplantation. Newer HLA A, B, C, DRB1, and DQB1 alleles, DPB1 mismatches, and HLA B leader sequence matching are incorporated into donor selection algorithms. Donor selection is highly relevant because of recently published conflicting studies using different donor types. These studies are largely retrospective and compare patients with different diseases and stages, conditioning regimens, graft versus host disease (GVHD) prophylaxis, and time periods. A broad consensus indicates that the best donor is an available matched sibling, followed by a matched unrelated donor, and then alternative donors such as haploidentical, mismatched unrelated, and cord blood units. This consensus is being challenged by other factors, such as donor age, patient condition, urgency of transplantation, and costs involved.SummaryIn this review, we will analyze the unique characteristics of each donor type, the HLA and non HLA factors that affect donor choices, and the outstanding comparative outcome studies of different donor usage in hematologic malignancies.
dc.fuente.origenWOS
dc.identifier.doi10.1097/MOH.0000000000000831
dc.identifier.eissn1531-7048
dc.identifier.issn1065-6251
dc.identifier.urihttps://doi.org/10.1097/MOH.0000000000000831
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90043
dc.identifier.wosidWOS:001321877900002
dc.issue.numero6
dc.language.isoen
dc.pagina.final269
dc.pagina.inicio261
dc.revistaCurrent opinion in hematology
dc.rightsacceso restringido
dc.subjectcord blood unit
dc.subjecthaploidentical donors
dc.subjectmatched siblings
dc.subjectstem cell donor selection
dc.subjectunrelated donors
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDonor selection in allogeneic stem cell transplantation
dc.typeartículo
dc.volumen31
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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