New steatotic liver disease criteria diagnostic performance in an agricultural population in Chile

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dc.article.number101919
dc.catalogadorpau
dc.contributor.authorSpencer Sandino, María de los Ángeles
dc.contributor.authorGodoy, Franco
dc.contributor.authorHuidobro, Laura
dc.contributor.authorAlvares, Danilo
dc.contributor.authorCruz, Francisco
dc.contributor.authorMarco, Claudia
dc.contributor.authorGarrido, Macarena
dc.contributor.authorCabrera, Daniel
dc.contributor.authorArab, Juan Pablo
dc.contributor.authorArrese, Marco
dc.contributor.authorBarrera Martínez, Francisco
dc.contributor.authorFerreccio Readi, Catterina
dc.date.accessioned2025-07-21T17:50:47Z
dc.date.available2025-07-21T17:50:47Z
dc.date.issued2025
dc.description.abstractIntroduction and Objectives: This study aims to assess the performance of Steatotic Liver Disease (SLD) criteria in identifying liver steatosis compared to the NAFLD and MAFLD definitions in an agricultural population in Chile. Patients and Methods: We performed a cross-sectional analysis on the MAUCO cohort, composed of 9,013 individuals aged 38 to 74. Health conditions, socio-demographics, anthropometrics, hepatic ultrasonography, blood pressure, and biological samples were obtained. Participants were classified as NAFLD, MAFLD, or any of the five SLD categories: Metabolic dysfunction-associated steatosis liver disease (MASLD), Metabolic and Alcohol-Associated Liver Disease (MetALD), Alcohol-Associated Liver Disease (ALD), Specific aetiologies, and Cryptogenic. The Framingham cardiovascular risk score and BARD liver fibrosis score were used to assess clinical relevance. Results: Liver steatosis was present in 4,082 participants (45%); SLD criteria captured an additional 176 individuals not classified under NAFLD and 103 not included under MAFLD definition. The main SLD subgroups were MASLD (95%), MetALD (1.9%) and ALD (1.3%). Individuals classified in the MetALD and ALD subgroups exhibited more severe liver steatosis and a higher cardiovascular risk. Notably, participants categorized under specific etiologies and cryptogenic subgroups were younger and had a higher risk for liver fibrosis. Conclusions: The study reveals that SLD offers a more inclusive classification to identify high-risk individuals in the Chilean population, capturing cases that could be missed by NAFLD or MAFLD definitions by using the same resources.
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.aohep.2025.101919
dc.identifier.urihttps://doi.org/10.1016/j.aohep.2025.101919
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104973
dc.information.autorucEscuela de Medicina; Spencer Sandino, María de los Ángeles; S/I; 1186485
dc.information.autorucEscuela de Medicina; Huidobro, Laura; S/I; 64852
dc.information.autorucEscuela de Medicina; Marco, Claudia; S/I; 15762
dc.information.autorucEscuela de Medicina; Garrido, Macarena; S/I; 1078613
dc.information.autorucEscuela de Medicina; Arab, Juan Pablo; 0000-0002-8561-396X; 132745
dc.information.autorucEscuela de Medicina; Arrese, Marco; 0000-0002-0499-4191; 76095
dc.information.autorucEscuela de Medicina; Barrera Martínez, Francisco; S/I; 1240448
dc.information.autorucEscuela de Medicina; Ferreccio Readi, Catterina; 0000-0001-6331-5534; 99684
dc.issue.numero2
dc.nota.accesocontenido completo
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleNew steatotic liver disease criteria diagnostic performance in an agricultural population in Chile
dc.typeartículo
dc.volumen30
sipa.codpersvinculados1186485
sipa.codpersvinculados64852
sipa.codpersvinculados15762
sipa.codpersvinculados1078613
sipa.codpersvinculados132745
sipa.codpersvinculados76095
sipa.codpersvinculados1240448
sipa.codpersvinculados99684
sipa.trazabilidadORCID;2025-07-07
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