Azocompounds as generators of defined radical species: Contributions and challenges for free radical research

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dc.catalogadorgjm
dc.contributor.authorLópez Alarcón, Camilo Ignacio
dc.contributor.authorFuentes Lemus, Eduardo Felipe
dc.contributor.authorFigueroa Alegría, Juan David
dc.contributor.authorDorta, Eva
dc.contributor.authorSchöneich, Christian
dc.contributor.authorDavies, Michael J.
dc.date.accessioned2024-12-30T13:43:17Z
dc.date.available2024-12-30T13:43:17Z
dc.date.issued2020
dc.description.abstractPeroxyl radicals participate in multiple processes involved in critical changes to cells, tissues, pharmacueticals and foods. Some of these reactions explain their association with degenerative pathologies, including cardiovascular and neurological diseases, as well as cancer development. Azocompounds, and particularly AAPH (2,2 ' Azobis(2-methylpropionamidine) dihydrochloride), a cationic water-soluble derivative, have been employed extensively as sources of model peroxyl radicals. A considerable number of studies have reported mechanistic data on the oxidation of biologically-relevant targets, the scavenging activity of foods and natural products, and the reactions with, and responses of, cultured cells. However, despite the (supposed) experimental simplicity of using azocompounds, the chemistry of peroxyl radical production and subsequent reactions is complicated, and not always considered in sufficient depth when analyzing experimental data. The present work discusses the chemical aspects of azocompounds as generators of peroxyl (and other) radicals, together with their contribution to our understanding of biochemistry, pharmaceutical and food chemistry research. The evidence supporting a role for the formation of alkoxyl (RO center dot) and other radicals during thermal and photochemical decomposition of azocompounds is assessed, together with the potential influence of such species on the reactions under study.
dc.format.extent14 páginas
dc.fuente.origenConveris
dc.identifier.doi10.1016/j.freeradbiomed.2020.06.021
dc.identifier.issn0891-5849
dc.identifier.pubmedid32771519
dc.identifier.urihttps://doi.org/10.1016/j.freeradbiomed.2020.06.021
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/89356
dc.identifier.wosidWOS:000595854700009
dc.information.autorucEscuela de Química; López Alarcón, Camilo Ignacio; S/I; 1004308
dc.information.autorucEscuela de Química; Fuentes Lemus, Eduardo Felipe; 0000-0002-1465-8466; 186720
dc.information.autorucEscuela de Química; Figueroa Alegría, Juan David; S/I; 1071087
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final91
dc.pagina.inicio78
dc.revistaFree Radical Biology and Medicine
dc.rightsacceso restringido
dc.subjectPeroxyl radicals
dc.subjectAzocompounds
dc.subjectAAPH
dc.subjectProtein oxidation
dc.subjectErythrocytes
dc.subjectCell cultures
dc.subjectNatural products
dc.subjectFoods
dc.subjectScavenging activity
dc.subjectAlkoxyl radicals
dc.subject.ddc510
dc.subject.deweyMatemática física y químicaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAzocompounds as generators of defined radical species: Contributions and challenges for free radical research
dc.typeartículo de revisión
dc.volumen160
sipa.codpersvinculados1004308
sipa.codpersvinculados186720
sipa.codpersvinculados1071087
sipa.trazabilidadConveris;20-07-2021
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