Synaptic Impairment in Layer 1 of the Prefrontal Cortex Induced by Repeated Stress During Adolescence is Reversed in Adulthood

Simple item page
dc.contributor.authorNegron-Oyarzo, Ignacio
dc.contributor.authorDagnino-Subiabre, Alexies
dc.contributor.authorMunoz Carvajal, Pablo
dc.date.accessioned2025-01-23T21:33:26Z
dc.date.available2025-01-23T21:33:26Z
dc.date.issued2015
dc.description.abstractChronic stress is a risk factor for the development of psychiatric disorders, some of which involve dysfunction of the prefrontal cortex (PFC). There is a higher prevalence of these chronic stress-related psychiatric disorders during adolescence, when the PFC has not yet fully matured. In the present work we studied the effect of repeated stress during adolescence on synaptic function in the PFC in adolescence and adulthood. To this end, adolescent Sprague-Dawley rats were subjected to seven consecutive days of restraint stress. Afterward, both synaptic transmission and short- and long-term synaptic plasticity were evaluated in layer 1 of medial-PFC (mPFC) slices from adolescent and adult rats. We found that repeated stress significantly reduced the amplitude of evoked field excitatory post-synaptic potential (fEPSP) in the mPFC. Isolation of excitatory transmission reveled that lower-amplitude fEPSPs were associated with a reduction in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor mediated transmission. We also found that repeated stress significantly decreased long-term depression (LTD). Interestingly, AMPA/kainate receptor-mediated transmission and LTD were recovered in adult animals that experienced a three-week stress-free recovery period. The data indicates that the changes in synaptic transmission and plasticity in the mPFC induced by repeated stress during adolescence are reversed in adulthood after a stress-free period.
dc.fuente.origenWOS
dc.identifier.doi10.3389/fncel.2015.00442
dc.identifier.eissn1662-5102
dc.identifier.urihttps://doi.org/10.3389/fncel.2015.00442
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101516
dc.identifier.wosidWOS:000364430100001
dc.language.isoen
dc.revistaFrontiers in cellular neuroscience
dc.rightsacceso restringido
dc.subjectrepeated stress
dc.subjectsynaptic plasticity
dc.subjectprefrontal cortex
dc.subjectadolescence
dc.subjectlong-term depression
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSynaptic Impairment in Layer 1 of the Prefrontal Cortex Induced by Repeated Stress During Adolescence is Reversed in Adulthood
dc.typeartículo
dc.volumen9
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas