Performance of the 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease in a Latin American Cohort

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dc.contributor.authorMartin-Nares, Eduardo
dc.contributor.authorHernandez-Molina, Gabriela
dc.contributor.authorBaenas, Diego Federico
dc.contributor.authorDelgado de la Mora, Jesus
dc.contributor.authorCaeiro, Francisco
dc.contributor.authorWurmann Kiblisky, Pamela
dc.contributor.authorPimentel-Quiroz, Victor R.
dc.contributor.authorAscuna Valdivia, Valery
dc.contributor.authorFaz-Munoz, David
dc.contributor.authorSaad, Emanuel Jose
dc.contributor.authorCairoli, Ernesto
dc.contributor.authorElgueta Pinochet, Sergio
dc.contributor.authorMadariaga Charaja, Hugo
dc.contributor.authorMontante-Montes de Oca, Daniel
dc.contributor.authorGallo, Jesica Romina
dc.contributor.authorUgarte-Gil, Manuel F.
dc.contributor.authorNeira, Oscar
dc.contributor.authorBurgos, Paula I.
dc.contributor.authorPaira, Sergio
dc.date.accessioned2025-01-20T17:08:09Z
dc.date.available2025-01-20T17:08:09Z
dc.date.issued2024
dc.description.abstractBackground/ObjectiveThe 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria (2019 AECC) for IgG4-related disease (IgG4-RD) is considered a significant advancement in the study of this condition. Most studies evaluating their performance have focused on White and Asian patients, leaving a knowledge gap regarding Latin American populations. Therefore, this study aimed to assess the performance of the 2019 AECC for IgG4-RD in a cohort of Latin American patients.MethodsA multicenter medical records review study was conducted, involving centers from Argentina, Chile, Mexico, Peru, and Uruguay. Data on IgG4-RD patients and mimicker conditions were collected through a standardized online form. The criterion standard for diagnosing IgG4-RD was based on the fulfillment of the Comprehensive Diagnostic Criteria for IgG4-RD and/or the Consensus Statement on Pathology. The 2019 AECC was retrospectively applied.ResultsWe included 300 patients, with 180 (60%) having IgG4-RD and 120 (40%) having mimicker conditions. The 2019 AECC had a sensitivity of 66.7% and a specificity of 100%. Sensitivity increased to 73.3% when disease-specific autoantibody items were removed, without affecting specificity. The true-positive cases had more involved organs, a higher availability of biopsy results, and were more likely to belong to the Mikulicz/systemic and proliferative phenotypes.ConclusionsThe use of the 2019 AECC for IgG4-RD in a Latin American population confirms its high specificity in excluding those without the disease. The presence of concomitant autoimmune diseases and clinically nonsignificant disease-specific autoantibodies excludes a significant number of patients from fulfilling the criteria.
dc.fuente.origenWOS
dc.identifier.doi10.1097/RHU.0000000000002052
dc.identifier.eissn1536-7355
dc.identifier.issn1076-1608
dc.identifier.urihttps://doi.org/10.1097/RHU.0000000000002052
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90922
dc.identifier.wosidWOS:001167932200009
dc.issue.numero2
dc.language.isoen
dc.pagina.final57
dc.pagina.inicio52
dc.revistaJcr-journal of clinical rheumatology
dc.rightsacceso restringido
dc.subjectimmunoglobulin G4-related disease
dc.subjectLatin American
dc.subjectclassification criteria
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePerformance of the 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease in a Latin American Cohort
dc.typeartículo
dc.volumen30
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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