Gallbladder motility and lithogenesis in obese patients during diet-induced weight loss

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dc.contributor.authorZapata, R
dc.contributor.authorSeverín, C
dc.contributor.authorManríquez, M
dc.contributor.authorValdivieso, V
dc.date.accessioned2025-01-21T01:31:36Z
dc.date.available2025-01-21T01:31:36Z
dc.date.issued2000
dc.description.abstractObesity and weight loss are important risk factors for gallstone development. The mechanisms involved are unknown. We prospectively studied changes in gallbladder (GB) emptying and bile composition during weight loss. We studied 12 alithiasic obese subjects who entered a six-month diet program (800-1200 kcal/day, 26 g fat/day). As controls we evaluated 12 healthy nulliparous nonobese young women. GB volumes were studied by ultrasonography (fasting volume, GBFV; residual volume after a liquid meal, GBRV) at entry and after 4 and 20 weeks of dieting. Bile acid pool size, biliary lipid composition, presence of cholesterol crystals, and nucleation time were also studied. Of 12 obese subjects studied (mean BMI 35.1 kg/m(2)), 10 remained in the program for six months, but only six completed the entire study protocol, obtaining a significant weight loss (BMI: 31.2 kg/m(2), P < 0.001). GBFV was greater in obese subjects than in nonobese controls (27.5 +/- 10.7 vs 11.7 +/- 6 mi; P < 0.05). GBRV and GB emptying curves were similar in both groups and did not change during weight loss. The obese subject who developed gallstones (1/10) was the only one who had cholesterol crystals in bile and a sluggish initial GB emptying. In conclusion: (1) obese subjects had a greater GBFV than controls; however, the GB emptying was adequate. (2) During weight loss we did not observe significant changes in GB kinetics or the bile parameters studied. (3) We observed a relatively low frequency of gallstone formation, which can be explained by a high fat content of the diet (26 g/day) and by the adequate GB emptying of our group of patients. (4) An abnormal GB contractility and cholesterol crystals in bile could be considered premonitory to gallstone formation.
dc.fuente.origenWOS
dc.identifier.eissn1573-2568
dc.identifier.issn0163-2116
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97102
dc.identifier.wosidWOS:000085705200035
dc.issue.numero2
dc.language.isoen
dc.pagina.final428
dc.pagina.inicio421
dc.revistaDigestive diseases and sciences
dc.rightsacceso restringido
dc.subjectcholelithiasis
dc.subjectgallbladder emptying
dc.subjectobesity
dc.subjectweight loss
dc.subjectdietary fats
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGallbladder motility and lithogenesis in obese patients during diet-induced weight loss
dc.typeartículo
dc.volumen45
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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