Carotid body inflammation and cardiorespiratory alterations in intermittent hypoxia

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dc.contributor.authorDel Rio, Rodrigo
dc.contributor.authorMoya, Esteban A.
dc.contributor.authorParga, Maria J.
dc.contributor.authorMadrid, Carlos
dc.contributor.authorIturriaga, Rodrigo
dc.date.accessioned2025-01-20T23:58:06Z
dc.date.available2025-01-20T23:58:06Z
dc.date.issued2012
dc.description.abstractChronic intermittent hypoxia (CIH), a main feature of obstructive sleep apnoea (OSA), increases hypoxic ventilatory responses and elicits hypertension, partially attributed to an enhance carotid body (CB) responsiveness to hypoxia. As inflammation has been involved in CIH-induced hypertension and chemosensory potentiation, we tested whether ibuprofen may block CB chemosensory and cardiorespiratory alterations induced by CIH in a rat model of OSA.
dc.description.abstractWe studied the effects of ibuprofen (40 mg(.)kg(-1.)day(-1)) on immunohistochemical interleukin (IL)-1 beta and tumour necrosis factor (TNF)-alpha levels in the CB, the number of c-fos-positive neurons in the nucleus tractus solitarii (NTS), CB chemosensory and ventilatory responses to hypoxia, and arterial blood pressure in male rats either exposed for 21 days to 5% O-2 (12 episodes(.)h(-1), 8 h(.)day(-1)) or kept under sham condition.
dc.description.abstractCIH increased CB TNF-alpha and IL-1 beta and c-fos-positive neurons in the NTS, enhanced carotid chemosensory and ventilatory hypoxic responses, and produced hypertension. Ibuprofen prevented CB cytokine overexpression and CIH-induced increases in c-fos-positive neurons in the NTS, the enhanced hypoxic ventilatory responses and hypertension, but failed to impede the CB chemosensory potentiation.
dc.description.abstractResults suggest that pro-inflammatory cytokines may contribute to the CIH-induced cardiorespiratory alterations, acting at several levels of the hypoxic chemoreflex and cardiovascular control pathways.
dc.description.funderFONDECYT
dc.fuente.origenWOS
dc.identifier.doi10.1183/09031936.00141511
dc.identifier.eissn1399-3003
dc.identifier.issn0903-1936
dc.identifier.urihttps://doi.org/10.1183/09031936.00141511
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95231
dc.identifier.wosidWOS:000305369900031
dc.issue.numero6
dc.language.isoen
dc.pagina.final1500
dc.pagina.inicio1492
dc.revistaEuropean respiratory journal
dc.rightsacceso restringido
dc.subjectHypertension
dc.subjecthypoxia
dc.subjectinflammation
dc.subjectobstructive sleep apnoea
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCarotid body inflammation and cardiorespiratory alterations in intermittent hypoxia
dc.typeartículo
dc.volumen39
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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