t(1;5)(q23;q33) in a patient with high-risk B-lineage acute lymphoblastic leukemia

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dc.contributor.authorBarriga, F
dc.contributor.authorBertin, P
dc.contributor.authorLegues, E
dc.contributor.authorRisueno, C
dc.contributor.authorAndrade, W
dc.contributor.authorCabrera, E
dc.contributor.authorGrebe, G
dc.date.accessioned2025-01-21T01:34:07Z
dc.date.available2025-01-21T01:34:07Z
dc.date.issued1996
dc.description.abstractThe t(1;5)(q23;q33) is a rare genetic anomaly that was reported previously in two infants with a myeloproliferative disorder and eosinophilia and in one adult patient with acute nonlymphocytic leukemia (ANLL). A 13-year-old boy with high-risk early pre-B acute lymphoblastic leukemia (ALL) who presented to our institution carried the t(1;5)(q23;q33). He had an initial blast count of 230 x 10(9)/L and responded poorly to prednisone. Complete remission ICR) was achieved, and he had a bone marrow (BM) relapse 3 months after despite intensive consolidation therapy He underwent allogeneic BM transplantation (BMT) from a human leukocyte antigen (HLA)-identical sibling in early relapse with total body irradiation (TBI) and cyclophosphamide conditioning. He had a short second CR with a central nervous system (CNS) relapse on day +106 after BMT. Two of the previously reported patients also did not respond to chemotherapy. The t(1;5)(q23;q33) appears to be a rare lineage nonspecific anomaly related to hematologic malignancies that are resistant to current therapy.
dc.fuente.origenWOS
dc.identifier.issn0165-4608
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97516
dc.identifier.wosidWOS:A1996UD43100002
dc.issue.numero1
dc.language.isoen
dc.pagina.final6
dc.pagina.inicio4
dc.revistaCancer genetics and cytogenetics
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlet(1;5)(q23;q33) in a patient with high-risk B-lineage acute lymphoblastic leukemia
dc.typeartículo
dc.volumen87
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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