A new antitubercular mulinane diterpenoid from <i>Azorella madreporica </i>Clos

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dc.contributor.authorWächter, GA
dc.contributor.authorFranzblau, SG
dc.contributor.authorMontenegro, G
dc.contributor.authorSuarez, E
dc.contributor.authorFortunato, RH
dc.contributor.authorSaavedra, E
dc.contributor.authorTimmermann, BN
dc.date.accessioned2025-01-21T01:32:37Z
dc.date.available2025-01-21T01:32:37Z
dc.date.issued1998
dc.description.abstractBioactivity-guided fractionation of the petroleum ether extract of Azorella madreporica Clos has led to the isolation of the novel, antitubercular mulinane diterpenoid 1. The structure has been elucidated on the basis of its 1D and 2D NMR spectra and by comparison with mulinolic acid 2 and a dehydration product 3 obtained from 1. The MIC of 1 for growth inhibition of the H(37)Rv Strain of Mycobacterium tuberculosis' was determined as 20 mu g/mL. LC-MS and NMR have suggested the presence of this new compound in four other species of Azorella.
dc.description.funderNIEHS NIH HHS
dc.fuente.origenWOS
dc.identifier.issn0163-3864
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97292
dc.identifier.wosidWOS:000075175900024
dc.issue.numero7
dc.language.isoen
dc.pagina.final968
dc.pagina.inicio965
dc.revistaJournal of natural products
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleA new antitubercular mulinane diterpenoid from <i>Azorella madreporica </i>Clos
dc.typeartículo
dc.volumen61
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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