Effects of leucine intake on muscle growth, strength, and recovery in young active adults: a systematic review of randomized controlled trials

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dc.catalogadorjwg
dc.contributor.authorRivera-Bermudez, Geison
dc.contributor.authorPizarro-Segura, Maria Fernanda
dc.contributor.authorQuesada-Quesada, Dayana
dc.contributor.authorSegura Bujan, Marco Vinicio
dc.contributor.authorZare, Reza
dc.contributor.authorGomez, Georgina
dc.contributor.authorAragon, Alan A.
dc.date.accessioned2025-03-18T14:09:39Z
dc.date.available2025-03-18T14:09:39Z
dc.date.issued2025
dc.description.abstractPurposeLeucine is an essential branched-chain amino acid required for skeletal muscle protein synthesis as a substrate and as a key anabolic signaling molecule primarily via activation of the mTORC1. Leucine supplementation has been proposed to enhance muscle adaptations, with some studies showing improvements in muscle growth. However, results from randomized controlled trials (RCTs) have been inconclusive, potentially due to variations in resistance exercise protocols and Leu dose or duration of supplementation. This systematic review explores the effects of leucine supplementation on resistance-training-induced muscle growth, strength, and recovery in healthy individuals.MethodsA systematic literature search was conducted across multiple databases (MedLine, EMBASE, PubMed, Science Direct, Scopus, and Cochrane) to identify RCTs investigating the effect of leucine intake on markers of muscle growth, strength, and recovery in trained adults aged 18 to 40 years old.ResultsA total of 14 RCTs were identified including acute (n = 5) and chronic leucine (n = 9) supplementation. A total of 13 studies did not find significant differences in muscle mass, strength, or recovery between leucine-supplemented and placebo groups.ConclusionsThe evidence from this systematic review suggests that leucine supplementation does not confer significant benefits in muscle growth, strength, or recovery in healthy, trained young adults.
dc.description.funderFood Science and Nutrition" of the University of Cambridge ReachSci Society
dc.fuente.origenORCID
dc.identifier.doi10.1186/s41110-025-00311-z
dc.identifier.eissn2316-7874
dc.identifier.urihttps://doi.org/10.1186/s41110-025-00311-z
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102724
dc.identifier.wosidWOS:001413927600001
dc.information.autorucActividades Universitarias-Dri; Segura Bujan, Marco Vinicio; S/I; 1097572
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherSPRINGERNATURE
dc.revistaNUTRIRE
dc.rightsacceso restringido
dc.subjectMuscle growth
dc.subjectMuscle strength
dc.subjectMuscle recovery
dc.subjectMuscle protein remodeling
dc.subjectMuscle hypertrophy
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEffects of leucine intake on muscle growth, strength, and recovery in young active adults: a systematic review of randomized controlled trials
dc.typeartículo
dc.volumen50
sipa.codpersvinculados1097572
sipa.trazabilidadORCID;2025-03-03
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