Solvent-Free Synthesis of New Quinoline Derivatives <i>via</i> Eaton's Reagent Catalysed Friedlander Synthesis

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dc.contributor.authorSatheeshkumar, Rajendran
dc.contributor.authorPrasad, Karnam Jayarampillai Rajendra
dc.contributor.authorWang Wen-Long
dc.contributor.authorEspinosa-Bustos, Christian
dc.contributor.authorSalas, Cristian O.
dc.date.accessioned2025-01-20T21:12:55Z
dc.date.available2025-01-20T21:12:55Z
dc.date.issued2022
dc.description.abstractAn interest for the development of new 2-acetyl/propanoyl quinolines via Friedlander synthesis is one of the most studied synthetic approaches. Herein we report the use of a freshly prepared Eaton's reagent (phosphorus pentoxide in methanesulfonic acid) as catalyst without solvents to obtain quinoline derivatives. Eleven 2-acetylquinolines were synthesized in high yields (85-96%) from symmetrical 1,2-diketone, butan-2,3-dione with o-aminoarylketones in the presence of Eaton's reagent. Subsequently, a novel regioselective solvent free reaction is reported for synthesis of o-aminoarylketones with unsymmetrical 1,2-diketone, pentan-2,3-dione, to yield different 2-propanoylquinolines. Eaton's reagent performs a unique way of this reaction as a powerful desiccant, condensing, cyclizing and dehydrating agent. Among these advantages of Eaton's reagent was found as an inexpensive and easily accessible catalyst for the Friedlander synthesis.
dc.description.funderFONDECYT
dc.fuente.origenWOS
dc.identifier.doi10.1002/slct.202104416
dc.identifier.issn2365-6549
dc.identifier.urihttps://doi.org/10.1002/slct.202104416
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93681
dc.identifier.wosidWOS:000757485500007
dc.issue.numero7
dc.language.isoen
dc.revistaChemistryselect
dc.rightsacceso restringido
dc.subject2-Acetyl quinolines
dc.subjectEaton's reagent
dc.subjectFriedlander synthesis
dc.subjectSolvent free synthesis
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSolvent-Free Synthesis of New Quinoline Derivatives <i>via</i> Eaton's Reagent Catalysed Friedlander Synthesis
dc.typeartículo
dc.volumen7
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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