Extremely and very preterm children who were born appropriate for gestational age show no differences in cortisol concentrations or diurnal rhythms compared to full-term children

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dc.contributor.authorDominguez-Menendez, Gonzalo
dc.contributor.authorPoggi, Helena
dc.contributor.authorOchoa-Molina, Fernanda
dc.contributor.authorD'Apremont, Ivonne
dc.contributor.authorMoore, Rosario
dc.contributor.authorAllende, Fidel
dc.contributor.authorSolari, Sandra
dc.contributor.authorMartinez-Aguayo, Alejandro
dc.date.accessioned2025-01-20T17:32:50Z
dc.date.available2025-01-20T17:32:50Z
dc.date.issued2023
dc.description.abstractObjectives: The objective of this study was to compare the diurnal variations in cortisol and cortisone concentrations in serum and saliva among extremely preterm (EPT), very preterm (VPT), and full-term (FT) children, all born appropriate for gestational age (AGA).Methods: EPT, VPT, and FT children, all born AGA, were recruited from two healthcare centers. Cortisol and cortisone concentrations in serum and saliva were measured by liquid chromatography-mass spectrometry (LC-MS). Statistical analysis was performed using nonparametric tests.Results: A total of 101 children (5.0-8.9 years old) were included in this study: EPT=18, VPT=43 and FT=40. All groups had similar distributions in terms of age, birth weight standard deviation score (SDS) and BMI (SDS), showing no differences in serum ACTH, cortisol, or cortisone levels. Additionally, salivary cortisol and cortisone concentrations decreased significantly throughout the day (p values<0.0001). Salivary cortisol concentrations were below the limit of detection (0.55 nmol/L) before dinner and before bedtime in approximately one-third and two-thirds of all children, respectively. Salivary cortisone was detectable in all but one sample.Conclusions: The diurnal cortisol rhythm was preserved in all preterm children, regardless of their gestational age, and no differences in cortisol concentrations among the groups were found. This may have significant implications for the clinical management and follow-up of preterm individuals.
dc.fuente.origenWOS
dc.identifier.doi10.1515/jpem-2023-0194
dc.identifier.eissn2191-0251
dc.identifier.issn0334-018X
dc.identifier.urihttps://doi.org/10.1515/jpem-2023-0194
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91633
dc.identifier.wosidWOS:001080958700001
dc.issue.numero11
dc.language.isoen
dc.pagina.final1027
dc.pagina.inicio1018
dc.revistaJournal of pediatric endocrinology & metabolism
dc.rightsacceso restringido
dc.subjectcortisol
dc.subjectcortisone
dc.subjectvery preterm
dc.subjectextremely preterm
dc.subjectappropriate for gestational age
dc.subjectdiurnal rhythm
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExtremely and very preterm children who were born appropriate for gestational age show no differences in cortisol concentrations or diurnal rhythms compared to full-term children
dc.typeartículo
dc.volumen36
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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