Atypical ductal hyperplasia in men with gynecomastia: what is their breast cancer risk?

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dc.catalogadorpva
dc.contributor.authorCoopey, Suzanne B.
dc.contributor.author Kartal, Kinyas
dc.contributor.authorLi, Clara
dc.contributor.authorYala, Adam
dc.contributor.authorBarzilay, Regina
dc.contributor.authorFaulkner, Heather R.
dc.contributor.authorKing, Tari A.
dc.contributor.authorAcevedo Claros, Francisco Nicolás
dc.contributor.authorGuidi, Anthony J.
dc.contributor.authorHughes, Kevin S.
dc.date.accessioned2024-01-19T18:21:50Z
dc.date.available2024-01-19T18:21:50Z
dc.date.issued2019
dc.description.abstractPurpose Atypical ductal hyperplasia (ADH) significantly increases the risk of breast cancer in women. However, little is known about the implications of ADH in men. Methods Review of 932 males with breast pathology was performed to identify cases of ADH. Patients were excluded if ADH was upgraded to cancer on excision, or if they had contralateral breast cancer. Cases were reviewed to determine whether any male with ADH developed breast cancer. Results Nineteen males were diagnosed with ADH from June 2003 to September 2018. All had gynecomastia. Surgical procedure was mastectomy in 8 patients and excision/reduction in 11. One patient had their nipple areola complex removed, and 1 required a free nipple graft. Median patient age at ADH diagnosis was 25 years (range 18–72 years). Of the 14 patients with bilateral gynecomastia, 10 had bilateral ADH and 4 had unilateral. Five cases of ADH were described as severe, bordering on ductal carcinoma in situ. No patient reported a family history of breast cancer. No patient took tamoxifen. At a mean follow-up of 75 months (range 4–185 months), no patient developed breast cancer. Conclusion Our study is the first to provide follow-up information for males with ADH. With 6 years of mean follow-up, no male in our series has developed breast cancer. This suggests that either ADH in men does not pose the same risk as ADH in women or that surgical excision of symptomatic gynecomastia in men effectively reduces the risk of breast cancer.
dc.fechaingreso.objetodigital2024-01-29
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1007/s10549-018-05117-4
dc.identifier.urihttps://doi.org/10.1007/s10549-018-05117-4
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80813
dc.identifier.wosidWOS:000466424600001
dc.information.autorucEscuela de Medicina; Acevedo Claros, Francisco Nicolás; 0000-0003-3482-7746; 119540
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final4
dc.pagina.inicio1
dc.revistaBreast Cancer Research and Treatment
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAtypical ductal hyperplasia in men with gynecomastia: what is their breast cancer risk?
dc.typeartículo
dc.volumen175
sipa.codpersvinculados119540
sipa.trazabilidadORCID;2024-01-08
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