Phonological and Semantic Fluency in Alzheimer's Disease: A Systematic Review and Meta-Analysis

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dc.article.number84226
dc.contributor.authorOlmos-Villasenor R.
dc.contributor.authorSepulveda-Silva C.
dc.contributor.authorJulio-Ramos T.
dc.contributor.authorFuentes-Lopez E.
dc.contributor.authorToloza-Ramirez D.
dc.contributor.authorSantibanez R.A.
dc.contributor.authorCopland D.A.
dc.contributor.authorMendez-Orellana C.
dc.date.accessioned2024-10-15T07:00:09Z
dc.date.available2024-10-15T07:00:09Z
dc.date.issued2023
dc.description.abstractBACKGROUND: Semantic and Phonological fluency (SF and PF) are routinely evaluated in patients with Alzheimer's disease (AD). There are disagreements in the literature regarding which fluency task is more affected while developing AD. Most studies focus on SF assessment, given its connection with the temporoparietal amnesic system. PF is less reported, it is related to working memory, which is also impaired in probable and diagnosed AD. Differentiating between performance on these tasks might be informative in early AD diagnosis, providing an accurate linguistic profile. OBJECTIVE: Compare SF and PF performance in healthy volunteers, volunteers with probable AD, and patients with AD diagnosis, considering the heterogeneity of age, gender, and educational level variables. METHODS: A total of 8 studies were included for meta-analysis, reaching a sample size of 1,270 individuals (568 patients diagnosed with AD, 340 with probable AD diagnosis, and 362 healthy volunteers). RESULTS: The three groups consistently performed better on SF than PF. When progressing to a diagnosis of AD, we observed a significant difference in SF and PF performance across our 3 groups of interest (p = 0.04). The age variable explained a proportion of this difference in task performance across the groups, and as age increases, both tasks equally worsen. CONCLUSION: The performance of SF and PF might play a differential role in early AD diagnosis. These tasks rely on partially different neural bases of language processing. They are thus worth exploring independently in diagnosing normal aging and its transition to pathological stages, including probable and diagnosed AD.
dc.description.funderCentro de Excelencia Severo Ochoa 2019-2023
dc.description.funderGovernment of Catalonia, Spain
dc.description.funderNational Institute on Alcohol Abuse and Alcoholism
dc.description.funderSpanish Ministry of Science, Innovation and Universities
dc.description.funderFondo Nacional de Desarrollo Científico y Tecnológico
dc.description.funderANID
dc.format.extent559 páginas
dc.fuente.origenScopus
dc.identifier.doi10.3233/JAD-221272
dc.identifier.eissn17482801
dc.identifier.issn18758908
dc.identifier.pubmedid35430032
dc.identifier.scopusidSCOPUS_ID:85169765149
dc.identifier.urihttps://doi.org/10.3233/JAD-221272
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88218
dc.identifier.wosidWOS:001061059100001
dc.information.autorucFacultad de Medicina; Fuentes Lopez, Eduardo; S/I; 1013849
dc.issue.numero6
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final12
dc.pagina.inicio1
dc.relation.ispartofThe Lancet Gastroenterology and Hepatology
dc.revistaJournal of Alzheimer's disease : JAD
dc.rightsacceso abierto
dc.subjectAlzheimer’s disease
dc.subjectphonemic fluency
dc.subjectsemantic fluency
dc.subjectverbal fluency
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePhonological and Semantic Fluency in Alzheimer's Disease: A Systematic Review and Meta-Analysis
dc.typeartículo
dc.volumen95
sipa.codpersvinculados1013849
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;15-10-2024
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