FERTILITY INHIBITION BY INTRA-OVIDUCTAL COPPER BEADS IN RABBITS

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dc.contributor.authorQUIJADA, S
dc.contributor.authorSOZA, X
dc.contributor.authorCROXATTO, HB
dc.date.accessioned2025-01-23T19:44:51Z
dc.date.available2025-01-23T19:44:51Z
dc.date.issued1978
dc.description.abstractThe effect of intraoviductal Cu upon fertility was studied in rabbits. Cu spheres (1 Cu or 5 Cu) were inserted in the ampulla of 1 oviduct and the same number of Ag spheres (1 Ag or 5 Ag) were inserted in the contralateral tube. After a recovery period, the animals were mated with fertile males and sacrificed 1 or 12 days after mating. Partial or total loss of spheres from the oviduct was observed in some animals, more so in the group with 5 beads sacrificed on day 12 of pregnancy. The ovulatory response, as judged by the number of corpora lutea, was normal and was not different between sides, or between groups. The rate of recovery of ova, and their distribution in the genital tract 1 day after mating was normal, indicating no effect of type or number of spheres upon ovum transport at this stage. The number of cleaved ova was significantly reduced by 1 Cu, as compared to 1 Ag, and by 5 Cu, as compared to 5 Ag or 1 Cu. One or 5 Cu spheres completely inhibited implantation in the adjacent uterine horn. Implantation rate in the side bearing 1 Ag was normal, whereas on the side bearing 5 Ag it was significantly reduced. Metallic Cu can apparently exert a contraceptive action at the level of the oviduct by interference with the earliest stages of pregnancy. The implications of these findings for the mode of action of Cu IUD [Intrauterine devices] are discussed.
dc.fuente.origenWOS
dc.identifier.eissn1879-0518
dc.identifier.issn0010-7824
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100142
dc.identifier.wosidWOS:A1978FD59500007
dc.issue.numero6
dc.language.isoen
dc.pagina.final562
dc.pagina.inicio553
dc.revistaContraception
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleFERTILITY INHIBITION BY INTRA-OVIDUCTAL COPPER BEADS IN RABBITS
dc.typeartículo
dc.volumen17
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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