VAS-DEFERENS DESENSITIZATION BY NORADRENALINE AND OTHER DRUGS

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dc.contributor.authorMIRANDA, H
dc.date.accessioned2025-01-23T19:45:05Z
dc.date.available2025-01-23T19:45:05Z
dc.date.issued1976
dc.description.abstractDesensitization of the isolated rat vas deferens was demonstrated by using noradrenaline, 5-hydroxytryptamine, carbachol, acetylcholine or BaCl2 as a test concentration after a large concentration (concentration producing a contraction that was 80% of the maximum) of the same agonist. The large concentration of noradrenaline caused desensitization in response to 5-hydroxytryptamine and acetylcholine but not to carbachol and BaCl2. Desensitization is not altered by reserpine.sbd.in pretreatment of rats with reserpine or reserpine in Tyrode solution.sbd.imipramine and 6-hydroxydopamine. Surgical denervation or modification of the Na and Ca concentration of the Tyrode solution did not either alter desensitization. Results show that in the rat isolated vas deferens desensitization is not mediated by an action of noradrenaline on the adrenergic neuron.
dc.fuente.origenWOS
dc.identifier.issn0003-9780
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100201
dc.identifier.wosidWOS:A1976BV68400006
dc.issue.numero2
dc.language.isoen
dc.pagina.final234
dc.pagina.inicio223
dc.revistaArchives internationales de pharmacodynamie et de therapie
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleVAS-DEFERENS DESENSITIZATION BY NORADRENALINE AND OTHER DRUGS
dc.typeartículo
dc.volumen221
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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