Puberty in chronic inflammatory conditions

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dc.catalogadorpva
dc.contributor.authorGrob Lunecke, Francisca
dc.contributor.authorZacharin, Margaret
dc.date.accessioned2023-05-19T20:51:14Z
dc.date.available2023-05-19T20:51:14Z
dc.date.issued2020
dc.description.abstractPuberty in chronic conditions may be severely delayed or arrested, with resultant poor linear growth, potential truncation of final height, and reduced peak bone mass, thus significantly increasing osteoporosis risk throughout adulthood. Systemic inflammatory cytokines, malnutrition, and use of glucocorticoids all affect the hypothalamic pituitary gonadal axis. Endocrine outcomes are influenced by ability to reduce disease activity and relapse. Introduction of new therapeutic agents with promising results, together with improvements in nutritional management and reduction of glucocorticoids, has changed the trajectory of many chronic inflammatory conditions. However, despite therapeutic improvement occurring over recent years, pubertal delay remains a frequent complication. Timely and repeated assessment and intervention is imperative, to avoid short- and long-term adverse consequences of lack of appropriate sex steroids on linear growth, pubertal maturation, psychosocial and emotional maturity.
dc.fechaingreso.objetodigital2023-07-07
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.coemr.2020.04.009
dc.identifier.issn2451-9650
dc.identifier.urihttps://doi.org/10.1016/j.coemr.2020.04.009
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/70444
dc.information.autorucEscuela de medicina;Grob Lunecke, Francisca;0000-0001-7685-9311;209562
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final36
dc.pagina.inicio29
dc.revistaCurrent Opinion in Endocrine and Metabolic Researches_ES
dc.rightsacceso restringido
dc.subjectDelayed pubertyes_ES
dc.subjectInflammatory diseasees_ES
dc.subjectBone mineral densityes_ES
dc.subjectFracturees_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titlePuberty in chronic inflammatory conditionses_ES
dc.typeartículo
dc.volumen14
sipa.codpersvinculados209562
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