Humoral waning kinetics against SARS-CoV-2 is dictated by disease severity and vaccine platform

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dc.catalogadorgjm
dc.contributor.authorTong, Xin
dc.contributor.authorKellman, Benjamin
dc.contributor.authorAvendaño Valenzuela, María José
dc.contributor.authorMendu, Maanasa
dc.contributor.authorHsiao, Jeff C.
dc.contributor.authorSerrano García, Eileen Francisca
dc.contributor.authorGarcía Salum, Tamara Cristal
dc.contributor.authorMuena, Nicolás
dc.contributor.authorPardo Roa, Catalina
dc.contributor.authorMorales, Mauricio
dc.contributor.authorLevicán Asenjo, Jorge Enrique
dc.contributor.authorSalinas Ortiz, Erick David
dc.contributor.authorCárdenas-Cáceres, Simone
dc.contributor.authorRiquelme Pérez, Arnoldo
dc.contributor.authorTischler, Nicole D.
dc.contributor.authorLauffenburger, Douglas A.
dc.contributor.authorAlter, Galit
dc.contributor.authorMcNamara, Ryan P.
dc.contributor.authorMedina, Rafael
dc.date.accessioned2025-06-27T13:24:14Z
dc.date.available2025-06-27T13:24:14Z
dc.date.issued2024
dc.description.abstractSARS-CoV-2 vaccine-acquired immunity provides robust cross-variant recognition, while infection-acquired immunity can be heterogenous, with disease severity often modulating post-recovery responses. We assessed antibody waning dynamics between infection- and vaccination-acquired immunity across variants of concern (VOC). mRNA vaccination induced potent, cross-VOC Spike recognition and functional responses, but waned more rapidly for Omicron Spike. Hospitalized individuals developed more durable functional responses with lower peaks compared to mRNA vaccination, while outpatients exhibited slower decay than inactivated vaccine recipients. Humoral decay for the receptor binding domain tracked with neutralizing antibody titers, while S2-directed responses tracked with antibody-dependent myeloid cellular phagocytosis. Boosting the recovered patients with mRNA or inactivated vaccines expanded humoral breadth, durability, and restored functional responses, eliminating the severity- and platform-associated decay differences. Therefore, post-recovery hybrid immunization compensates for this distinction and broadens humoral breadth, highlighting the value of boosting immunity in previously infected individuals.
dc.fechaingreso.objetodigital2025-06-27
dc.format.extent27 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1101/2024.10.17.24315607
dc.identifier.urihttps://doi.org/10.1101/2024.10.17.24315607
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-85211356405&partnerID=MN8TOARS
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104776
dc.information.autorucFacultad de Ciencias Biológicas; Avendaño Valenzuela, María José; S/I; 1086420
dc.information.autorucFacultad de Ciencias Biológicas; Serrano García, Eileen Francisca; S/I; 1086419
dc.information.autorucFacultad de Ciencias Biológicas; García Salum, Tamara Cristal; S/I; 121228
dc.information.autorucFacultad de Ciencias Biológicas; Muena, Nicolás; S/I; 149729
dc.information.autorucFacultad de Ciencias Biológicas; Pardo Roa, Catalina; 0000-0002-5409-225X; 225251
dc.information.autorucS/I; Levicán Asenjo, Jorge Enrique; S/I; 114062
dc.information.autorucEscuela de Medicina; Salinas Ortiz, Erick David; S/I; 1101975
dc.information.autorucEscuela de Medicina; Riquelme Pérez, Arnoldo; 0000-0002-8259-8960; 3538
dc.information.autorucEscuela de Medicina; Medina, Rafael; 0000-0002-5013-6884; 1000649
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistamedRxiv
dc.rightsacceso abierto
dc.rights.licenseCC BY-NC-ND 4.0 Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHumoral waning kinetics against SARS-CoV-2 is dictated by disease severity and vaccine platform
dc.typepreprint
sipa.codpersvinculados1086420
sipa.codpersvinculados1086419
sipa.codpersvinculados121228
sipa.codpersvinculados149729
sipa.codpersvinculados225251
sipa.codpersvinculados114062
sipa.codpersvinculados1101975
sipa.codpersvinculados3538
sipa.codpersvinculados1000649
sipa.trazabilidadORCID;2025-06-23
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