Isolated duodenal exclusion increases energy expenditure and improves glucose homeostasis in diet-induced obese rats

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dc.contributor.authorMunoz, Rodrigo
dc.contributor.authorCarmody, Jill S.
dc.contributor.authorStylopoulos, Nicholas
dc.contributor.authorDavis, Philip
dc.contributor.authorKaplan, Lee M.
dc.date.accessioned2025-01-20T23:56:40Z
dc.date.available2025-01-20T23:56:40Z
dc.date.issued2012
dc.description.abstractMunoz R, Carmody JS, Stylopoulos N, Davis P, Kaplan LM. Isolated duodenal exclusion increases energy expenditure and improves glucose homeostasis in diet-induced obese rats. Am J Physiol Regul Integr Comp Physiol 303: R985-R993, 2012. First published September 12, 2012; doi:10.1152/ajpregu.00262.2012.-Roux-en-Y gastric bypass (RYGB) in rodent models reduces food intake (FI), increases resting energy expenditure (EE), and improves glycemic control. We have shown that mimicking the duodenal component of RYGB by implantation of a 10-cm endoluminal sleeve device (ELS-10) induces weight loss and improves glycemic control in diet-induced obese (DIO) rats. We sought to determine the mechanisms and structural requirements of these effects. We examined the effects of ELS-10 devices implanted in male DIO rats on body weight, food intake (FI), meal patterns, total and resting EE, and multiple parameters of glucose homeostasis, comparing them with sham-operated (SO) rats and with SO rats weight matched to the ELS-10-treated group. To determine the extent of duodenal exclusion required to influence metabolic outcomes, we compared the effects of implanting 10-, 4-, or 1-cm ELS devices. ELS-10 rats exhibited 13% higher total and 9% higher resting EE than SO controls. ELS-10 rats also exhibited enhanced postprandial GLP-1 secretion and improved glucose tolerance and insulin sensitivity out of proportion to the effects of weight loss alone. Implantation of 4- or 1-cm ELS devices had no effect on EE and limited effects on glucose homeostasis. Complete duodenal exclusion with ELS-10 induces weight loss by decreasing FI and increasing EE and improves glycemic control through weight loss-independent mechanisms. Thus signals originating in the proximal small intestine appear to exert a direct influence on the physiological regulation of EE and glucose homeostasis. Their selective manipulation could provide effective new therapies for obesity and diabetes that mimic the benefits of RYGB.
dc.fuente.origenWOS
dc.identifier.doi10.1152/ajpregu.00262.2012
dc.identifier.eissn1522-1490
dc.identifier.issn0363-6119
dc.identifier.urihttps://doi.org/10.1152/ajpregu.00262.2012
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95169
dc.identifier.wosidWOS:000311225000001
dc.issue.numero10
dc.language.isoen
dc.pagina.finalR993
dc.pagina.inicioR985
dc.revistaAmerican journal of physiology-regulatory integrative and comparative physiology
dc.rightsacceso restringido
dc.subjectdiabetes
dc.subjectbariatric surgery
dc.subjectenergy balance
dc.subjectmedical devices
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIsolated duodenal exclusion increases energy expenditure and improves glucose homeostasis in diet-induced obese rats
dc.typeartículo
dc.volumen303
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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